组织工程与重建外科杂志2025，Vol.21Issue(2)：148-156,9.DOI:10.3969/j.issn.1673-0364.2025.02.008
间充质干细胞分泌组治疗慢性创面的研究进展
Advances in mesenchymal stem cells secretome for the treatment of chronic wounds
王佳欣 1段育任 2王小兵3
作者信息
- 1. 030000 山西省太原市 山西医科大学
- 2. 100730 北京市 中国医学科学院北京协和医学院整形外科医院鼻整形科
- 3. 030000 山西省太原市 山西医科大学第一医院整形外科
- 折叠
摘要
Abstract
[Summary]Mesenchymal stem cells(MSCs)are widely used in the field of repair and regeneration because of their numerous biological effects.However,MSC cell therapy for chronic wounds has a number of drawbacks,including a limited ability to homing living cells,a lower survival rate,and the possibility of malignant differentiation.Recent advances have been made in the study of MSCs secretome,and cell-free therapy based on MSC secretome is considered to be a novel strategy for enhancing MSC bioavailability to treat chronic wounds.In this paper,the benefits of MSC secretome therapy,the mechanism by which the secretome acts on the wound,preconditioning methods to improve the secretome therapeutic potential were all discussed,and the research status of MSCs conditioned medium and MSCs extracellular vesicles was summarized,laying the groundwork for future clinical trials.关键词
间充质干细胞/分泌组/慢性创面/条件培养基/细胞外囊泡Key words
Mesenchymal stem cells/Secretome/Chronic wound/Conditioned medium/Extracellular vesicles分类
临床医学引用本文复制引用
王佳欣,段育任,王小兵..间充质干细胞分泌组治疗慢性创面的研究进展[J].组织工程与重建外科杂志,2025,21(2):148-156,9.
