组织工程与重建外科杂志2025，Vol.21Issue(2)：193-197,5.DOI:10.3969/j.issn.1673-0364.2025.02.015
长骨临界骨缺损动物模型评估可降解金属材料的研究进展
Research progress in animal models of critical-sized bone defects of long bones in evaluation of biodegradable metals
摘要
Abstract
[Summary]With increasing attention to biodegradable alloys for bone repair with good biocompatibility,mechanical properties,and osteogenic activity,the establishment of reproducible and practical animal models to evaluate their comprehensive performance plays an essential role before clinical application.Animal models such as rodents,rabbits,dogs,sheep,and pigs have been established to assess the availability and comparability of biodegradable alloys for bone repair,since their similar physiological and mechanical environment to the human body.Considering the differences in the size,quantity,implantation time,and biological response of biodegradable alloys for bone repair,low cost,easy access,tolerance to housing,and simple postoperative care and intervention procedure are important prerequisites for ideal animal models of critical-sized bone defects of long bone,to receive an adequate sample size in a short period.Therefore,the physiological characteristics,bone defect length,and repeatability of bone defect animal models using rodents,rabbits,dogs,sheep,and pigs were reviewed,to provide a reference for the study of biodegradable alloys.关键词
骨缺损/骨再生/生物活性材料/可降解合金/动物模型Key words
Bone defect/Bone regeneration/Bioactive materials/Biodegradable alloys/Animal model分类
医药卫生引用本文复制引用
刘凯,艾合买提江·玉素甫..长骨临界骨缺损动物模型评估可降解金属材料的研究进展[J].组织工程与重建外科杂志,2025,21(2):193-197,5.基金项目
中央引导地方科技发展资金资助项目(ZYYD2022A03). （ZYYD2022A03）
