组织工程与重建外科杂志2025，Vol.21Issue(2)：198-204,7.DOI:10.3969/j.issn.1673-0364.2025.02.016
间充质干细胞膜的生物学特性及应用
Biological characteristics and applications of mesenchymal stem cell membranes
摘要
Abstract
[Summary]Mesenchymal stem cells(MSCs)have been widely applied in cell therapy due to their multipotent differentiation capabilities,homing properties,and immunoregulatory functions.MSC membranes and their derivatives retain the membrane composition and biological characteristics of the source cells,and have gradually become a new focus of drug delivery research.MSC membranes can not only target diseased tissues but also modulate host immune responses through immunoregulatory molecules,thereby assisting in therapy.They demonstrate excellent targeting ability and biocompatibility in the treatment of diseases such as inflammation and tumors.However,the specific composition and corresponding functions of MSC membranes still require further investigation,and challenges remain in large-scale production and preservation for clinical applications.In this paper,the biological characteristics of MSC membranes and their applications in drug delivery and disease treatment were summarized,and the potential of engineering modifications to enhance targeting efficiency and therapeutic potential was discussed,providing a reference for the development of novel cell membrane therapies and carrier systems.关键词
间充质干细胞/细胞膜/药物递送/纳米颗粒Key words
Mesenchymal stem cells/Cell membranes/Drug delivery/Nanoparticles分类
生物学引用本文复制引用
王昱欢,钱姝桐,胡哲原,孙晓明,王丹茹..间充质干细胞膜的生物学特性及应用[J].组织工程与重建外科杂志,2025,21(2):198-204,7.基金项目
上海交通大学医学院附属第九人民医院优秀青年学者基金(JYYQ011) （JYYQ011）
国家自然科学基金(822772263) （822772263）
上海市科学技术委员会临床医学研究中心项目(22MC1940300). （22MC1940300）
