现代牧业2025，Vol.9Issue(1)：13-18,6.
白消安消除鸡内源性原始生殖细胞的作用机制与应用研究
Mechanism and application of busulfan in the clearance of endogenous primordial germ cells in chickens
彭溢秀1
作者信息
- 1. 扬州大学 动物科学与技术学院,江苏 扬州 225100
- 折叠
摘要
Abstract
As a traditional alkylating anticancer drug,Busulfan is widely used in clinical treatment,but its reproductive toxicity is significant.In recent years,attention has been paid to the elimination of endogenous primordial germ cells(PGCs)by Busulfan in chicken embryos.PGCs,as germ cell precursor cells,play a key role in the development of the reproductive system and the transmission of genetic information.And the elimination of endogenous PGCs provides an ideal experimental platform for studying the reconstruction of the reproductive system and the construction of gene editing technology and transgenic models.In this paper,we reviewed the mechanism of action,application methods and potential applications of busulfan in the elimination of chicken PGCs in transgenic technology,genetic improvement and species conservation.By analyzing the existing research results and challenges,this review provides references for further applications of busulfan in reproductive biology and agriculture in the future,and discusses the ethical issues and development direction of this technology.关键词
白消安/消除/原始生殖细胞/鸡Key words
Busulfan/clearance/PGC/chicken分类
农业科技引用本文复制引用
彭溢秀..白消安消除鸡内源性原始生殖细胞的作用机制与应用研究[J].现代牧业,2025,9(1):13-18,6.
