动物医学进展2025，Vol.46Issue(7)：104-109,6.
硫酸乙酰肝素生物合成及修饰过程中关键酶的功能研究进展
Advances in Biosynthesis of Heparan Sulfate and the Biological Functions of Key Modifying Enzymes
摘要
Abstract
Heparan sulfate(HS)is a linear isomeric polysaccharide composed of multiple highly sulfated uronic acid and glucosamine bisaccharide repeat units.HS acts as a cell surface receptor and binds to cyto-kines and a variety of virions including foot-and-mouth disease virus(FMDV),playing important and ex-tensive roles in biological functions.The synthesis of functional HS macromolecules includes both intracel-lular biosynthesis and extracellular post-synthetic modification processes,which involves the participation of many enzymes.In this paper,the process of HS biosynthesis and modification was reviewed from the per-spective of polysaccharide polymerization and protein modification,and the key enzymes and functions in-volved were summarized,which would provide theoretical references for the further study of biological functions and chemical enzymatic synthesis of HS.关键词
硫酸乙酰肝素/生物合成/合成后修饰/生物学功能Key words
Heparan sulfate/Biosynthesis/Enzyme/Post-synthetic modification/Biological function引用本文复制引用
黄磊,白兴文,袁红,宫晓华,包慧芳,李冬,李平花,孙普,卢曾军,刘在新..硫酸乙酰肝素生物合成及修饰过程中关键酶的功能研究进展[J].动物医学进展,2025,46(7):104-109,6.基金项目
国家重点研发计划项目(2021YFD1800300) （2021YFD1800300）
国家自然科学基金面上项目(31772763) （31772763）
甘肃省重大科技专项(21ZD3NA001,22ZD6NA012,22ZD6NA001) （21ZD3NA001,22ZD6NA012,22ZD6NA001）
国家生猪技术创新中心项目(NCTIP-XD/C03) （NCTIP-XD/C03）
