动物医学进展2025，Vol.46Issue(7)：110-114,5.
细菌鞭毛蛋白作为新型佐剂和免疫治疗剂的研究进展
Progress on Bacterial Flagellin as a Novel Adjuvant and Immunotherapeutic Agent
摘要
Abstract
In recent years,numerous microbial components have been utilized as immune enhancers to par-ticipate in the immune response to antigens,thereby improving the immune response of vaccines with poor immunogenicity.As a potent agonist,flagellin can activate Toll-like receptor 5(TLR5)and NOD-like re-ceptor containing a caspase activation and recruitment domain 4(NLRC4)signaling pathways,thus stimu-lating both the innate and adaptive immune responses of the body.Furthermore,flagellin possesses advan-tages such as low toxicity,ease of preparation,and significant potential for modification,making it a prom-ising candidate as an adjuvant and immunotherapeutic agent with considerable clinical application pros-pects.This overview systematically examines the structure and immunostimulatory effects of flagellin,with a particular focus on its research advancements as an immune adjuvant and therapeutic agent.Additionally,we explore the potential application value of flagellin in vaccine research and development,as well as in an-ti-tumor and anti-radiation therapies.Through an in-depth analysis of the characteristics and functions of flagellin,we aim to provide new insights and methodologies for future biomedical research.关键词
鞭毛蛋白/佐剂/免疫治疗剂/信号通路/疫苗Key words
Flagellin/Adjuvant/Immunotherapeutic agent/Signal pathway/Vaccine分类
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周桂仙,吴诗卉,王敏乐,廖义潇,李双,杨泽敏,鲜思美,杨颖..细菌鞭毛蛋白作为新型佐剂和免疫治疗剂的研究进展[J].动物医学进展,2025,46(7):110-114,5.基金项目
贵州省基础研究计划项目(黔科合基础-ZK[2023]一般105):贵州省科技成果转化项目(一般项目)(黔科合成果[2024]一般104号) （黔科合基础-ZK[2023]一般105）
