吉林医药学院学报2025，Vol.46Issue(3)：161-165,170,6.
超临界CO2流体萃取姜黄素条件优化及纯度鉴定
Optimization of Curcumin Conditions and Purity Identification of Supercritical CO2 Fluid Extraction
摘要
Abstract
Objective The purpose of this study was to optimize the process parameters of supercritical CO2 fluid extraction of curcumin,and to improve the extraction efficiency and purity.Methods The effects of extraction pressure,temperature,CO2 flow rate,time,and particle size on extraction effect were systematically investigated by single factor test combined with L9(35)orthogonal test,and the purity of curcumin was determined by high performance liquid chromatography(HPLC).Results The extraction amount of curcumin in-creased significantly at first and then tended to be stable with the increase of extraction pressure,reaching 14.2 mg/g at 30 MPa,and the highest extraction amount(12.80 mg/g)at 55℃.When the CO2 flow rate was 20 mL/min,the extraction volume reached 10.25 mg/g,and the extraction growth rate slowed down after the time exceeded 2 h.The extraction efficiency was optimal when the particle size of the raw material was 50-100 μm(9.80 mg/g).The analysis of variance of orthogonal experiments showed that the order of influencing factors was extraction pressure>temperature>time>flow rate>particle size.Conclusion The optimal process conditions for supercritical CO2 fluid extraction of curcumin were as follows:pressure 30 MPa,temperature 55℃,flow rate 20 mL/min,time 2 h,particle size 50-100 μm,and the extraction rate of curcumin was 2.3%(purity 95.65%).关键词
姜黄/姜黄素/超临界CO2萃取Key words
Curcuma longa L./curcumin/supercritical CO2 extraction分类
轻工业引用本文复制引用
霍梦琦,陈百川,陈为,闫靖芸,孙成彪,许娜..超临界CO2流体萃取姜黄素条件优化及纯度鉴定[J].吉林医药学院学报,2025,46(3):161-165,170,6.基金项目
吉林省科技发展计划—农业关键技术研发—重点研发项目(20240303082NC) （20240303082NC）
