吉林医药学院学报2025，Vol.46Issue(3)：166-170,5.
基于不同载体材料的吲哚美辛无定形固体分散体的制备及体外评价
Preparation and in Vitro Evaluation of Indomethacin Amorphous Solid Disper-sions Based on Different Carrier Materials
摘要
Abstract
Objective The solid dispersion(SD)of Indomethacin(IND)was prepared to enhance the solubility and in vitro dissolution rate of IND.Methods HPMC and Soluplus were used as carriers to prepare IND-SD via the melt-quenching method.The IND raw drug,amorphous IND,physical mixture,and IND-SD were characterized by differential scanning calorimetry,X-ray diffraction,and Fourier transform infrared spectroscopy.The solubility and in vitro dissolution profiles of these formulations were also evaluated.Results The prepared IND-SD is in an amorphous state,and intermolecular interactions exist between IND and HPMC as well as Soluplus.The in vi-tro cumulative dissolution of IND-SD with Soluplus reached 95%within 120 minutes,showing a significant improvement in dissolution rate compared to IND,amorphous IND and their physical mixture.Conclusion IND-SD was successfully prepared by the melt-quenching method,which effectively improved the dissolution properties of IND.关键词
吲哚美辛/固体分散体/溶出度Key words
indomethacin/solid dispersion/dissolution分类
药学引用本文复制引用
张宏梅,崔佰吉,张天一,王丹,吴金滢..基于不同载体材料的吲哚美辛无定形固体分散体的制备及体外评价[J].吉林医药学院学报,2025,46(3):166-170,5.基金项目
吉林省教育厅项目(JJKH20210494KJ) （JJKH20210494KJ）
