吉林医药学院学报2025，Vol.46Issue(3)：171-175,179,6.
基于Fe基金属有机框架纳米载药体系的构建及体外抗肿瘤活性研究
Preparation and in Vitro Antitumor Activity of Fe-based Organic Framework Nano Drug Delivery System
摘要
Abstract
Objective To construct a kind of nanomaterial with chemodynamic-chemo synergistic treatment for tumor and improve the therapeutic effect.Methods Fe-MOF@DHA nanomaterial was prepared by using metal-organic framework(MOF)as drug carrier loaded with dihydroartemisinin(DHA).The morphology and stability of Fe-MOF@DHA nanoparticles were characterized by SEM and DLS.The drug release behavior of the nanoparticle and the production of ·OH were investigated by UV-vis.The inhibitory effect of Fe-MOF@DHA nanoparticle on hepatoma HepG2 cell proliferation was investigated by MTT method.Results ·OH can be produced by the interaction of the nanoparticle with H2O2.The loading efficiency of Fe-MOF nanoparticle for DHA was 25％.The drug release rate was higher at pH 5.0.Fe-MOF@DHA nanoparticle +H2O2 group showed the best inhibitory effect on HepG2 cells.Conclusion Fe-MOF@DHA nanoparticle can be used as an ideal chemodynamic-chemo synergistic therapeutic reagent,which can effectively improve the therapeutic effect of tumor.关键词
金属有机框架/纳米载药体系/双氢青蒿素/抗肿瘤Key words
metal-organic framework/nano drug delivery system/dihydroartemisinin/antitumor分类
临床医学引用本文复制引用
张雪莲,吴天鸥,李雯雯,周言,薛莹雪..基于Fe基金属有机框架纳米载药体系的构建及体外抗肿瘤活性研究[J].吉林医药学院学报,2025,46(3):171-175,179,6.基金项目
吉林省科技发展计划项目(YDZJ202401025ZYTS) （YDZJ202401025ZYTS）
吉林市科技创新发展计划项目(20230103033) （20230103033）
大学生创新创业训练计划项目(S202113706054,S202313706016) （S202113706054,S202313706016）
