吉林医药学院学报2025，Vol.46Issue(3)：176-179,4.
不同粒径药墨颗粒的止血性能评价
Evaluation of Hemostatic Properties of Yaomo Particles with Different Particle Sizes
摘要
Abstract
Objective To evaluate the hemostatic properties of Yaomo particles with different particle sizes.Methods Various sizes of Yaomo particles were prepared through differential centrifugation.The mice were divided into the blank group,Yunnan Baiyao group,Yaomo total particles group,Yaomo large particle group,Yaomo medium particle group,and Yaomo small particle group.Bleeding time(BT)and coagulation time(CT)of mice were assessed through tail amputation hemostasis and the glass slide method,respectively.Addi-tionally,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),and fibrinogen(FIB)concentra-tions were determined using an automated coagulation analyzer.Results The mass percentages of the large,medium,and small particles of Yaomo were 83.34%,11.41%,and 5.25%,respectively.The average particle size of the total particles of Yaomo was 459 nm,and the average particle sizes of the large,medium,and small particles of Yaomo were 712 nm,342 nm,and 164 nm,respectively.Compared with the blank group,4 kinds of Yaomo particles could effectively shorten the BT,CT,PT,and TT of mice(P<0.05),while there is no statisti-cally significant difference in APTT and FIB(P>0.05).Compared with the Yaomo total particles group,the small particles of Yaomo had a statistically significant effect on shortening BT,CT,PT,and TT in mice(P<0.05).Conclusion Yaomo particles could effectively acti-vate exogenous coagulation pathways and exert hemostatic effects,among which the small particles of Yaomo had the best hemostatic properties.关键词
药墨/粒径/止血性能Key words
Yaomo(Chinese traditional herbal ink)/particles size/hemostatic properties分类
中医学引用本文复制引用
李美惠,芦宁,李航,孙琳博,马瑞欣,隋春红..不同粒径药墨颗粒的止血性能评价[J].吉林医药学院学报,2025,46(3):176-179,4.基金项目
吉林省科技厅科技发展计划(YDZJ202401065ZYTS) （YDZJ202401065ZYTS）
2023年吉林省大学生创新创业训练项目(S202313706014) （S202313706014）
