分析化学2025，Vol.53Issue(5)：729-739,11.DOI:10.19756/j.issn.0253-3820.241351
构建式微流控芯片和可重构微流控芯片的研究与应用进展
Research and Application Progress of Configurable Microfluidics and Reconfigurable Microfluidics
摘要
Abstract
Microfluidic chips have revolutionized analytical sciences through miniaturization and high-throughput capabilities.However,conventional static devices are constrained by fixed architectures,functional rigidity,and high customization costs.In recent years,,the emerging configurable and reconfigurable microfluidic technologies have provided solutions for these limitations through dynamic adaptability.Configurable systems enable post-fabrication customization via modular assembly or boundary modification,offering cost-effective functional versatility.Reconfigurable microfluidics represents a more advanced paradigm,incorporating real-time decision-making and dynamic control through physical/virtual boundary adjustments during operation.These adaptive systems enable precise manipulation of microenvironments for applications ranging from single-cell manipulation to dynamic biochemical synthesis.In this review,a ″static-dynamic boundary″ framework to systematically analyze both technologies was proposed,and the design rationales,operational mechanisms,and implementation strategies were compared.The development history of these two techniques was introduced,and the applications demonstrated their transformative potential in developing intelligent lab-on-chip systems,while technical challenges in standardization and control interfaces were critically assessed.The development trend on integrating smart materials and AI-driven automation to advance next-generation adaptive microfluidic platforms was prospected.关键词
构建式微流控芯片/可重构微流控芯片/开放式微流控芯片/评述Key words
Configurable microfluidics/Reconfigurable microfluidics/Open microfluidics/Review引用本文复制引用
万芃晖,高克鑫,范一强..构建式微流控芯片和可重构微流控芯片的研究与应用进展[J].分析化学,2025,53(5):729-739,11.基金项目
南京理工大学2025年校自主科研项目资助. Supported by the Independent Research Project of Nanjing University of Science and Technology in 2025. （）
