分子影像学杂志2025，Vol.48Issue(5)：535-544,10.DOI:10.12122/j.issn.1674-4500.2025.05.02
静息态功能磁共振成像揭示重度抑郁障碍伴自伤行为患者的脑部自发神经活动异常
Resting-state functional magnetic resonance imaging reveals abnormal spontaneous neural activity in the brains of patients with depression accompanied by self-injurious behavior
摘要
Abstract
Objective To investigate the correlation between spontaneous neural activity and cognitive function in patients with major depressive disorder(MDD)accompanied by self-injurious behavior utilizing resting-state functional magnetic resonance imaging.Methods Adult patients with MDD(DSM-5)were recruited from the Department of Psychiatry and Psychology at Nanfang Hospital,Southern Medical University from June to December 2023.Adult patients were divided into MDD+NSSI group(n=29)and MDD-NSSI group(n=34).A healthy control group(HC,n=31),matched for age,gender,and education,was also recruited.All participants completed assessments(HAMD24,HAMA,C-SSRS,FASM),cognitive testing(ANT).This experiment analyzed the differences in brain functional activity and the statistically significant characteristics of brain regions among three groups by preprocessing the original image data of the subjects and extracting the fALFF values.Meanwhile,it explored the correlation between the signals of these brain regions and clinical data,revealing the potential link between brain functional abnormalities and clinical manifestations.Results In the MDD+NSSI group,the fALFF values were increased in the left middle frontal gyrus and right middle temporal gyrus(P<0.05)but decreased in the right anterior cingulate and paracingulate gyri(P<0.05).In the MDD-NSSI group,a decrease was observed in the right precuneus(P<0.05).The fALFF value in the left middle frontal gyrus of the MDD+NSSI group was positively correlated with HAMD scores(r=0.418,P=0.024),while in the MDD-NSSI group,the fALFF value in the right precuneus was positively correlated with HAMD scores(r=0.357,P=0.038).Additionally,in the MDD+NSSI group,the fALFF value in the left middle frontal gyrus was positively correlated with the one year C-SSRS score(r=0.396,P=0.034),while that in the right middle temporal gyrus was negatively correlated with the lifetime C-SSRS score(r=-0.390,P=0.037).Furthermore,the right anterior cingulate and paracingulate gyri showed negative correlations with the efficiency of the alerting network in the ANT test(r=-0.473,P=0.010).Conclusion The abnormal neural activities in the left middle frontal gyrus and right middle temporal gyrus of MDD+NSSI patients may reflect changes in impulse and emotion processing.The abnormalities in the anterior cingulate and posterior cingulate gyri show crossage consistency and affect alertness.The abnormality in the precuneus is only observed in MDD+NSSI patients,indicating different emotional and cognitive processing mechanisms in the two subtypes.关键词
静息态功能磁共振成像/自发神经活动/比率低频振幅/重度抑郁障碍/非自杀性自我伤害行为Key words
resting-state functional magnetic resonance imaging/spontaneous neural activity/fractional low-frequency amplitude/major depressive disorder(MDD)/non-suicidal self-injury behavior引用本文复制引用
陈志敏,高辽鸣,吴子琪,郑荣欣,尹红蕾,文戈..静息态功能磁共振成像揭示重度抑郁障碍伴自伤行为患者的脑部自发神经活动异常[J].分子影像学杂志,2025,48(5):535-544,10.基金项目
国家自然科学基金(82172012)Supported by National Natural Science Foundation of China(82172012). （82172012）
