分子影像学杂志2025，Vol.48Issue(5)：545-551,7.DOI:10.12122/j.issn.1674-4500.2025.05.03
3.0T MRI弥散张量成像对腰椎间盘退变的诊断价值
Diagnostic value of 3.0T MRI diffusion tensor imaging in lumbar intervertebral disc degeneration
摘要
Abstract
Objective To explore the diagnostic efficacy of 3.0T MRI diffusion tensor imaging(DTI)in lumbar disc degeneration and the correlation of clinical function.Methods A total of 85 patients with back and leg pain were selected from the First Affiliated Hospital of Bengbu Medical University from January 2024 to June 2024.Routine MRI and DTI sequence scanning were performed on all patients.The Pfirrmann grading scale was used to evaluate the degeneration of intervertebral discs from L3 to S1.The severity of lumbar pain and dysfunction was assessed using the visual analog scale(VAS),Oswestry disability index(ODI)and Japanese Orthopaedic Association(JOA)score.The fractional anisotropy(FA)and apparent diffusion coefficient(ADC)values of the nucleus pulposus region in each intervertebral disc from L3 to S1 were measured.Spearman correlation analysis was performed to investigate the relationship between FA and ADC values and Pfirrmann grading.ROC curves were used to evaluate the diagnostic efficiency of FA and ADC values for different grades of disc degeneration.Differences in VAS ODI,and JOA scores among patients with different Pfirrmann grades were compared.The linear correlation between FA and ADC values and VAS,ODI and JOA scores was analyzed.Results A total of 249 lumbar intervertebral discs were evaluated,with 63,98,60 and 28 discs classified as Pfirrmann grades Ⅱ,Ⅲ,Ⅳ,and Ⅴ,respectively.There were significant differences in FA and ADC values among all grades(P<0.05).Spearman correlation analysis showed that the Pfirrmann grade of disc degeneration was highly positively correlated with FA values(r=0.858,P<0.001)and highly negatively correlated with ADC values(r=-0.764,P<0.001).ROC curve analysis indicated that the diagnostic efficacy of FA and ADC values for differentiating grades Ⅱ-Ⅲ,Ⅲ-Ⅳ and Ⅳ-Ⅴ was 0.829,0.906,0.924 for FA and 0.776,0.854,0.869 for ADC,respectively.Pearson correlation analysis demonstrated significant correlations between FA and ADC values and VAS,ODI,and JOA scores(P<0.05).Conclusion 3.0 T MRI DTI can effectively and intuitively evaluate Pfirrmann grade and lumbar function of lumbar disc degeneration,which is helpful for clinical qualitative and quantitative diagnosis.关键词
磁共振成像/弥散张量成像/腰椎间盘退行性变/Pfirrmann分级Key words
magnetic resonance imaging/diffusion tensor imaging/lumbar disc degeneration/Pfirrmann grade引用本文复制引用
王志远,乔政,孟颖,张纪,李庆,陈刘成..3.0T MRI弥散张量成像对腰椎间盘退变的诊断价值[J].分子影像学杂志,2025,48(5):545-551,7.基金项目
安徽省高校自然科学重大项目(KJ2021ZD0089) （KJ2021ZD0089）
蚌埠医学院研究生科研创新项目(Byycx23095) （Byycx23095）
蚌埠市科技创新指导类项目(2024ZD0007) （2024ZD0007）
