分子影像学杂志2025，Vol.48Issue(5)：552-561,10.DOI:10.12122/j.issn.1674-4500.2025.05.04
肝动脉化疗栓塞术前预测肝癌患者的2年无进展生存时间的生存率:基于增强MRI不同瘤周影像组学
Prediction of 2-year PFS survival rate in hepatocellular carcinoma patients before TACE:based on different peritumoral radiomics of enhanced MRI
摘要
Abstract
Objective To explore the construction of different peritumoral prediction models based on enhanced MRI radiomics,and to predict the 2-year PFS survival rate of hepatocellular carcinoma patients before transarterial chemoembolization.Methods A total of 201 patients who received transarterial chemoembolization(TACE)treatment in interventional radiology center from the First Affiliated Hospital of Xinjiang Medical University from January 2021 to January 2023 were retrospectively collected.Patients included in the study underwent 3.0T enhanced MRI scan of upper abdomen one week before TACE.Based on the images of arterial phase,portal vein phase and delayed phase of enhanced MRI,the tumor region of interest(ROI)was delineated,and the tumor was expanded by 2,4,6 mm equidistantly,and the histological model of intra-tumor and different tumor weeks was constructed:intratumoral+peritumoral 2 mm model,intratumoral+peritumoral 4 mm model,intratumoral+peritumoral 6 mm model,Nomogram model.The effectiveness of the above model to understand the independent risk factors affecting prognosis and the prediction of survival rate were evaluated.Results In the training corhort and test corhort,the AUC efficiency of intra-tumor+peritumoral 6mm model was 0.997 and 0.966,respectively,and its intra-tumor+peritumoral 6mm model was better than intra-tumor+peritumoral 2 mm and 4 mm models.Combined with Nomogram model,intra-tumor+peritumoral 6 mm model showed good clinical predictive value;COX survival analysis showed that the predicted probability of intra-tumor+peritumoral 6 mm was an independent risk factor for PFS.Kaplan-Meier curve survival analysis showed that the prediction probability of intra-tumor+peritumoral 6 mm model was a risk factor affecting the prognosis(P<0.05),the median PFS in the high-risk group was 14.8 months(P<0.001)in the training corhort and the median PFS in the risk group was 12 months(P=0.001)in the test corhort.Conclusion The intra-tumor+peritumoral 6mm model based on enhanced MRI radiomics has good clinical application value in predicting the 2-year PFS survival rate before TACE,and it can become a new imaging biomarker in the future.关键词
肝细胞癌/经导管肝动脉栓塞术/磁共振/瘤周/无进展生存期Key words
hepatocellular carcinoma/transarterial chemoembolization/magnetic resonance/tumour margin/progression-free survival引用本文复制引用
管清龙,张海潇,任伟新..肝动脉化疗栓塞术前预测肝癌患者的2年无进展生存时间的生存率:基于增强MRI不同瘤周影像组学[J].分子影像学杂志,2025,48(5):552-561,10.基金项目
新疆维吾尔自治区科学技术厅自然科学基金面上项目(2022D01C490) （2022D01C490）
