分子影像学杂志2025，Vol.48Issue(5)：569-573,5.DOI:10.12122/j.issn.1674-4500.2025.05.06
黑质与红核铁沉积增加是特发性帕金森病运动障碍进展的潜在影像标志物:基于磁敏感加权成像
Increased iron deposition in the substantia nigra and red nucleus as potential imaging biomarkers for motor dysfunction progression in idiopathic Parkinson's disease:based on susceptibility-weighted imaging
摘要
Abstract
Objective To investigate the correlation between iron deposition in various brain nuclei and motor impairments as well as disease severity in idiopathic Parkinson's disease(iPD)patients using susceptibility weighted imaging(SWI),and to evaluate the potential application of SWI in monitoring disease progression and severity.Methods A total of 49 iPD patients(iPD group)and 70 age-and sex-matched healthy controls(control group)at Xiangyang No.1 People's Hospital,Hubei University of Medicine from September 2022 to September 2024 were recruited.All participants underwent SWI scanning on a 3.0T MRI scanner with specific parameters.The phase values of different brain nuclei were measured in the phase maps.The differences in phase values between the iPD group and healthy control group were compared.Additionally,the differences in phase values among iPD patients at different Hoehn-Yahr stages relative to healthy control group were analyzed.The correlation between phase values of each nucleus in the iPD group and Hoehn-Yahr stages and UPDRS scores was also examined.Results The phase values of the bilateral caudate,putamen,globus pallidus,red nucleus,and substantia nigra were significantly lower in the iPD group than in healthy control group(P<0.001).In iPD patients at different Hoehn-Yahr stages,the phase values in the substantia nigra(P<0.001)and red nucleus(P<0.001)were significantly reduced compared to healthy controls,with statistically significant differences.Specifically,the phase values of the substantia nigra and red nucleus in stage Ⅲ iPD patients were lower than those in stages Ⅱ and I(P<0.05).In the iPD group,the phase values of the bilateral substantia nigra(r=-0.468,P<0.001)and red nucleus(r=-0.404,P<0.001)showed a negative correlation with Hoehn-Yahr stages,and also exhibited a negative correlation with UPDRS-Ⅲ scores(r=-0.354,P<0.001;r=-0.359,P<0.001).Conclusion The findings indicate that iron deposition in the substantia nigra and red nucleus regions of iPD patients increases progressively with disease severity.This increased iron deposition is associated with motor impairments and overall disease severity,suggesting that it may serve as a potential biomarker for monitoring the progression and severity of iPD.关键词
特发性帕金森病/磁敏感加权成像/铁沉积Key words
idiopathic Parkinson's disease/susceptibility weighted imaging/iron deposition引用本文复制引用
杨超,周玲,陶晶,杨艳,赵传军,李霜..黑质与红核铁沉积增加是特发性帕金森病运动障碍进展的潜在影像标志物:基于磁敏感加权成像[J].分子影像学杂志,2025,48(5):569-573,5.基金项目
分子影像湖北省重点实验室开放基金项目(2024fzyx020) （2024fzyx020）
院级科技创新项目(XYY2025QN09) （XYY2025QN09）
