中国妇幼健康研究2025，Vol.36Issue(5)：24-30,7.DOI:10.3969/j.issn.1673-5293.2025.05.004
呼气末一氧化碳在新生儿黄疸住院评估中的应用研究
Study on the application of end-tidal carbon monoxide in the hospital evaluation of neonatal jaundice
摘要
Abstract
Objective To explore the role of end-tidal carbon monoxide(ETCO)in the hospital evaluation of neonatal jaundice and to provide a theoretical basis for expanding the clinical application of ETCO.Methods Newborns born between March 2021 and November 2022 at Xi'an People's Hospital(Xi'an Fourth Hospital)and hospitalized for jaundice were selected as study subjects.On the basis of routine treatment,ETCO measurements were performed.Using 1.60ppm as the cutoff value,the infants were divided into a high-level group(ETCO≥1.60ppm)and a low-level group(ETCO＜1.60ppm).Basic information such as gestational age,birth weight,sex,maternal pregnancy risk factors,and neonatal hemolysis test results was collected for both groups,along with hospitalization data including duration of hospital stay and total phototherapy time,for statistical analysis.Results There were no statistically significant differences between the high-level group and the low-level group in terms of gender,cesarean section rate,birth weight,maternal age at delivery,maternal complications(perinatal infection,premature rupture of membranes,hypothyroidism,gestational diabetes),umbilical cord abnormalities,amniotic fluid contamination,or positive hemolysis test results(P＞0.05).Gestational age at birth was significantly lower in the high-level group than in the low-level group(t=2.107,P=0.038).There were no significant differences in age at admission(in hours),total serum bilirubin(TSB),transcutaneous bilirubin(TcB),or TcB percentile at admission(P＞0.05).The rate of TcB increase during hospitalization was significantly higher in the high-level group than in the low-level group(t=3.091,P=0.003),and the duration of phototherapy was also significantly longer in the high-level group(t=2.449,P=0.017).However,there was no significant difference in the total length of hospital stay between the two groups(P＞0.05).ETCO was positively correlated with the rate of TcB increase(r=0.396,P＜0.001),but not with TSB(P＞0.05).Conclusion ETCO can reflect the rate of TcB increase in neonates with jaundice and help assess the required duration of phototherapy during hospitalization,indicating its potential clinical value for broader application.关键词
呼气末一氧化碳/新生儿/黄疸/高胆红素血症/光疗Key words
end-tidal carbon monoxide/neonate/jaundice/hyperbilirubinemia/phototherapy分类
预防医学引用本文复制引用
骆秋月,李井洋,王晓燕,雷喜梅,倪黎明,刘俐..呼气末一氧化碳在新生儿黄疸住院评估中的应用研究[J].中国妇幼健康研究,2025,36(5):24-30,7.基金项目
西安市人民医院(西安市第四医院)科研孵化基金项目(No.FZ-73) （西安市第四医院）
