中国妇幼健康研究2025，Vol.36Issue(5)：67-72,6.DOI:10.3969/j.issn.1673-5293.2025.05.010
高危型HPV感染状况、血清PTX3、TFF1表达与宫颈癌病变程度的相关性研究
Study on the correlation between high-risk HPV infection,serum PTX3 and TFF1 expression,and the severity of cervical cancer lesions
摘要
Abstract
Objective To analyze the status of high-risk human papillomavirus(HPV)infection,serum pentraxin 3(PTX3),and trefoil factor 1(TFF1)levels in cervical cancer patients and their correlation with the severity of cervical cancer lesions.Methods A total of 360 patients with high-grade squamous intraepithelial lesions(HSIL)who were admitted to our hospital from June 2021 to June 2023 were selected as the study subjects.Based on the final diagnosis,they were divided into a cervical cancer group(n=175)and a cervical intraepithelial neoplasia(CIN)group(n=185).Additionally,160 healthy women undergoing physical examinations during the same period were selected as the control group.The high-risk HPV infection status,serum PTX3 and TFF1 levels,and their correlation with the severity of cervical cancer lesions were compared among the groups.Results The high-risk HPV infection rate in the CINⅢ group(73.68％)was significantly higher than that in the control group(0.00％)and the CINⅠ group(35.29％)(P＜0.05).The high-risk HPV infection rates in the FIGO stage ⅠB(87.87％)and FIGO stage ⅡA cervical cancer groups(92.66％)were significantly higher than those in the control group(0.00％),CINⅠ group(35.29％),CINⅡ group(60.47％),and CINⅢ group(73.68％)(P＜0.05).There were statistically significant differences in serum PTX3 and TFF1 levels among the control,CIN,and cervical cancer groups(F=180.087 and 175.767,respectively,P＜0.05).The differences in serum PTX3 and TFF1 levels among different CIN lesions were also statistically significant(F=57.381 and 73.891,respectively,P＜0.05).Patients with FIGO stage ⅡA cervical cancer and those with lymph node metastasis had significantly higher serum PTX3 and TFF1 levels than patients with FIGO stage ⅠB cervical cancer and those without lymph node metastasis(t=7.262,6.429,8.107,and 5.587,respectively,P＜0.05).As the HPV viral load increased,serum PTX3 and TFF1 levels in cervical cancer patients showed a significant upward trend(F=88.169 and 85.550,respectively,P＜0.05).Additionally,lower tumor differentiation in cervical cancer patients was associated with higher serum PTX3 and TFF1 levels(F=110.194 and 111.731,respectively,P＜0.05).Conclusion The increased high-risk HPV infection rate and elevated serum PTX3 and TFF1 levels are closely associated with the severity of cervical cancer lesions.Clinically,timely monitoring of high-risk HPV infection status and changes in serum PTX3 and TFF1 levels may help assess the risk of cervical cancer development.关键词
宫颈癌/宫颈上皮内瘤变/高危型人乳头瘤病毒/正五聚蛋白3/三叶因子1Key words
cervical cancer/cervical intraepithelial neoplasia/high risk human papillomavirus/pentraxin-3/trefoil factor family 1分类
医药卫生引用本文复制引用
王琳辉,李春艳,杜晴,侯晓丹,崔敬,栗艳松..高危型HPV感染状况、血清PTX3、TFF1表达与宫颈癌病变程度的相关性研究[J].中国妇幼健康研究,2025,36(5):67-72,6.基金项目
衡水市科技计划项目(2023014059Z) （2023014059Z）
