临床与病理杂志2025，Vol.45Issue(2)：212-221,10.DOI:10.11817/j.issn.2095-6959.2025.241091
OCT和OCTA技术在神经退行性变性疾病诊断中的应用进展
Application progress in OCT and OCTA technologies for the diagnosis of neurodegenerative diseases
摘要
Abstract
The retinal microcirculation shares many similarities with cerebral small vessels.As a directly observable part of the central nervous system with clearly defined structural layers,the retina serves as an ideal model for studying the pathophysiology of central nervous system disorders.Neurodegenerative diseases are a group of chronic conditions characterized by neuronal degeneration or demyelination.Currently,diagnosis is primarily based on clinical symptoms and imaging findings;however,by the time a definitive diagnosis is made,irreversible neurological damage has often already occurred,severely affecting patient survival and quality of life.Optical coherence tomography(OCT)and optical coherence tomography angiography(OCTA)can provide detailed structural and vascular imaging of the retina,choroid,and optic nerve,enabling detection of subtle retinal changes and offering a window into central nervous system alterations.Understanding the OCT and OCTA characteristics of neurodegenerative diseases in recent years can provide a scientific basis for their early identification and intervention.关键词
光学相干断层/光学相干断层扫描血管造影/神经退行性疾病/视网膜/脉络膜Key words
optical coherence tomography/optical coherence tomography angiography/neurodegenerative diseases/retina/choroid引用本文复制引用
涂密密,彭立,谢青..OCT和OCTA技术在神经退行性变性疾病诊断中的应用进展[J].临床与病理杂志,2025,45(2):212-221,10.基金项目
海南省自然科学基金(821QN1005) （821QN1005）
海南省卫生健康科技创新联合项目(WSJK2024MS187) （WSJK2024MS187）
海南省重点研发-社会发展项目(ZDYF2020110) （ZDYF2020110）
海南省国际科技合作人才交流项目(G20230607013E).This work was supported by the Natural Science Foundation of Hainan Province(821QN1005),the Joint Program on Health Science&Technology Innovation of Hainan Province(WSJK2024MS187),the Key Reseach and Development Project of Social Science in Hainan Provice(ZDYF2020110),and the International Science&Technology Cooperation Talent Program of Hainan Province(G20230607013E),China. （G20230607013E）
