临床与病理杂志2025，Vol.45Issue(2)：222-229,8.DOI:10.11817/j.issn.2095-6959.2025.250033
钙黏蛋白-11在器官纤维化中作用的研究进展
Research progress in the role of cadherin-11 in organ fibrosis
何柔 1吴红赤1
作者信息
- 1. 哈尔滨医科大学附属第一医院肾内科,哈尔滨 150001
- 折叠
摘要
Abstract
Organ fibrosis is the terminal pathological process characterized by pathological extracellular matrix deposition leading to progressive organ dysfunction.Cadherin-11(CDH-11),a classical calcium-dependent cell adhesion molecule,plays a central regulatory role in the progression of fibrosis across multiple organs.In murine models of fibrosis affecting the lungs,liver,heart,kidneys,and skin,CDH-11 expression is consistently upregulated.Targeting CDH-11 specifically has been shown to mitigate fibrosis in various mouse models,confirming it as a shared mediator in inter-organ fibrotic processes.Although CDH-11-targeted therapies have shown promising outcomes in preclinical studies,further investigation is needed to evaluate their efficacy and safety in humans.关键词
器官纤维化/钙黏蛋白-11/治疗靶点/成纤维细胞/转化生长因子β1Key words
organ fibrosis/cadherin-11/therapeutic target/fibroblast/transforming growth factor β1引用本文复制引用
何柔,吴红赤..钙黏蛋白-11在器官纤维化中作用的研究进展[J].临床与病理杂志,2025,45(2):222-229,8.
