海南医科大学学报2025，Vol.31Issue(10)：771-785,15.DOI:10.13210/j.cnki.jhmu.20250310.002
中国人源黏液型铜绿假单胞菌抗生素耐药性的Meta分析
Antibiotic resistance of human mucinous Pseudomonas aeruginosa in China:A meta review
摘要
Abstract
Objective:To systematically review the resistance of patients with mucinous Pseudomonas aeruginosa infection to different antibiotics in China.Methods:CNKI,PubMed and other databases were electronically searched to collect studies on re-sistance of mucous Pseudomonas aeruginosa to different antibiotics from 1 January 2000 to 1 November 2024.Two review authors were responsible for searching and screening the literature,re-evaluating the risk of bias of the included studies based on the data collected,and then performing a meta-analysis of the specific data of all included studies using R version 4.4.Results:A total of 32 studies involving 2 483 strains of mucoid Pseudomonas aeruginosa were included.The results of meta-analysis showed that:The top three antibiotic resistance rates of mucoid Pseudomonas aeruginosa were aztreonam 24%(95%CI 18%-29%),ciprofloxa-cin 23%(95%CI 17%-30%)and piperacillin 18%(95%CI 13%-24%).The three antibiotics with low resistance were imipenem 7%(95%CI 3%-12%),amikacin 6%(95%CI 3%-9%),and 6%(95%CI 2%-10%).Subgroup analysis of the three classes of antibiotics with high resistance rates showed that the resistance rates before 2010 were generally lower than those during 2011-2021.The drug resistance rate in east China and North China was higher than that in Southwest China.Conclusion:Current evidence shows that the resistance rate of Chinese mucinous Pseudomonas aeruginosa to amtronam,ciprofloxacin and piperacillin was higher,and it was more sensitive to meropenem,imipenem and amikacin.There were differences in drug resistance rates at different times and regions.关键词
黏液型铜绿假单胞菌/抗生素/耐药/Meta分析Key words
Muciod Pseudomonas aeruginosa/Antibiotic/Resistance rate/Meta-analysis分类
临床医学引用本文复制引用
张郴燕,孙峥科,梁文娟,龙文芳,黄海溶..中国人源黏液型铜绿假单胞菌抗生素耐药性的Meta分析[J].海南医科大学学报,2025,31(10):771-785,15.基金项目
This study was supported by Hainan Provincial Health Commission Statistical Information Center Project(C2024010216) 海南省卫生健康委员会统计信息中心立项课题(C2024010216) （C2024010216）
