海南医科大学学报2025，Vol.31Issue(10)：786-792,7.DOI:10.13210/j.cnki.jhmu.20250225.002
线粒体自噬与支气管哮喘相关性的研究进展
Research progress on the relationship between mitochondrial autophagy and bronchial asthma
摘要
Abstract
Bronchial asthma is a common chronic airway disease,and its pathogenesis remains to be further studied.The au-tophagy mechanism that maintains mitochondrial homeostasis and clears aging and damaged mitochondria is called mitochondrial autophagy.Dysregulation of mitochondrial autophagy induces excessive production of mitochondrial reactive oxygen species(mtROS)and secretion of various inflammatory cytokines and proteins,aggravating the progression of asthma.The removal of damaged mitochondria is essential for maintaining cell balance,and is closely related to the survival and development of asthma pa-tients.In this paper,we reviewed the relevant studies on the pathogenesis of bronchial asthma,in order to provide a new perspec-tive for the in-depth study of bronchial asthma.关键词
线粒体自噬/支气管哮喘/气道免疫炎症/气道重塑/线粒体活性氧Key words
Mitochondrial autophagy/Bronchial asthma/Airway immunoinflammation/Airway remodeling/Mitochondrial reactive oxygen species分类
临床医学引用本文复制引用
张令雯,蔡兴俊..线粒体自噬与支气管哮喘相关性的研究进展[J].海南医科大学学报,2025,31(10):786-792,7.基金项目
This study was supported by National Natural Science Foundation of China(82360009,81860007) 国家自然科学基金资助项目(82360009,81860007) （82360009,81860007）
