神经损伤与功能重建2025，Vol.20Issue(5)：280-283,4.DOI:10.16780/j.cnki.sjssgncj.20230805
小胶质细胞在帕金森病中的作用机制及免疫疗法
The Mechanism and Immunotherapy of Microglia in Parkinson's Disease
摘要
Abstract
Parkinson's disease(PD)is the second most prevalent neurodegenerative disorder worldwide,with complex and diverse pathological factors.Chronic,persistent stimulation-induced neuroinflammation stands as one of the major pathological contributors.During the pathogenesis of PD,the misfolding of α-synuclein and the release of mitochondrial DNA(mtDNA)due to mitochondrial damage both induce the activation of microglia,disrupting the balance of inflammatory cytokines in the brain region and leading to neuronal injury.Consequently,the inflammatory response mediated by microglia serves as a critical link in the pathogenesis of PD and represents one of the most promising therapeutic targets.Therefore,this review summarizes the origin,types,and functions of microglia,as well as their potential mechanisms in the pathogenesis of PD and PD therapies targeting microglia,aiming to provide a deeper understanding of the role played by microglia in PD and the underlying potential therapeutic strategies.关键词
帕金森病/小胶质细胞/神经炎症/多巴胺能神经元/α-突触核蛋白Key words
Parkinson's disease/microglia/neuroinflammation/dopaminergic neurons/α-synuclein分类
临床医学引用本文复制引用
成慧灵,张楚天,许茜,周美,王林,蔡晶..小胶质细胞在帕金森病中的作用机制及免疫疗法[J].神经损伤与功能重建,2025,20(5):280-283,4.基金项目
国家自然科学基金项目(苁蓉舒痉颗粒调节MAMs区域钙稳态保护多巴胺神经元的分子机制研究,No.82074507) （苁蓉舒痉颗粒调节MAMs区域钙稳态保护多巴胺神经元的分子机制研究,No.82074507）
2021-2024年福建省中医药研究项目计划(补肾益髓方通过内质网-线粒体轴保护PD鼠DA能神经元的作用机制研究,No.2021ZYJC02) （补肾益髓方通过内质网-线粒体轴保护PD鼠DA能神经元的作用机制研究,No.2021ZYJC02）
