神经损伤与功能重建2025，Vol.20Issue(5)：284-287,306,5.DOI:10.16780/j.cnki.sjssgncj.20240289
电针治疗中枢神经系统疾病的免疫炎症机制研究进展
Research Progress on the Immunoinflammatory Mechanism of Electroacupuncture in the Treatment of Central Nervous System Diseases
摘要
Abstract
The broad immune response of the central nervous system(CNS)includes innate immune response and adaptive immune response,involving a variety of immune effector cells.Hyperimmune-induced neuroinflammation is a key process in most neurological diseases,even more damaging than the primary damage.At present,the neuroimmunotherapy for CNS diseases mainly focuses on drugs.Electroacupuncture,has the characteristics of few side effects and high safety,and the therapeutic effect in the treatment of the CNS diseases has been confirmed,but the biological mechanism involved in the therapeutic effect is more complex.Starting from neuroinflammation induced by neuroimmune system activation,this paper summarizes the types of immune effector cells that play a major role in CNS diseases in recent years,describes the mechanism of immune cells,and discusses the molecular biological mechanism of how electroacupuncture can inhibit neuroinflammation by regulating the neuro-immune system and immune effector cells to treat diseases.关键词
电针/中枢神经系统/免疫系统/神经炎症Key words
electroacupuncture/central nervous system/immune system/neuroinflammation分类
医药卫生引用本文复制引用
李佳诺,曾祥新,郭玉怀,孙敏,田洪昭,尹洪娜..电针治疗中枢神经系统疾病的免疫炎症机制研究进展[J].神经损伤与功能重建,2025,20(5):284-287,306,5.基金项目
黑龙江省博士后面上资助项目(基于TXNIP NLRP3信号通路研究电针对脊髓损伤后认知障碍中内质网应激诱发细胞焦亡的作用机制,No.LBH-Z22280) （基于TXNIP NLRP3信号通路研究电针对脊髓损伤后认知障碍中内质网应激诱发细胞焦亡的作用机制,No.LBH-Z22280）
国家自然科学基金面上项目(基于NLRP3 STAT3信号通路介导的焦亡-自噬Crosstalk的夹脊电针促进脊髓损伤修复的神经元再生机制,No.81873378) （基于NLRP3 STAT3信号通路介导的焦亡-自噬Crosstalk的夹脊电针促进脊髓损伤修复的神经元再生机制,No.81873378）
