神经损伤与功能重建2025，Vol.20Issue(5)：293-295,310,4.DOI:10.16780/j.cnki.sjssgncj.20230787
Toll样受体2/3/4与新生儿脑损伤的研究进展
The Role of Toll-like Receptor 2/3/4 in Neonatal Brain Injury
摘要
Abstract
The mechanism of the occurrence and development of neonatal brain injury remains largely unknown,but the inflammatory damage has been recognized to play an important role.As an important receptor for the innate immune response,the Toll-like receptor-related signaling pathway is closely related to the activation of inflammation.Toll-like receptor family members TLR2,TLR3 and TLR4 could promote the expression of inflammatory cytokines through various mechanisms,thereby affecting the progression and prognosis of neonatal brain injury.The authors now review the research progress of TLR 2,TLR 3 and TLR 4 in neonatal brain injury,in order to provide help for the mechanistic understanding of the disease,and also provide some ideas and reference for the drug development of targeted Toll-like receptors that can be used in the treatment of neonatal brain injury.关键词
Toll样受体/TLR2/TLR3/TLR4/新生儿脑损伤Key words
Toll like receptors/TLR2/TLR3/TLR4/neonatal brain injury分类
临床医学引用本文复制引用
黄润芝,李宇宁,曹长青..Toll样受体2/3/4与新生儿脑损伤的研究进展[J].神经损伤与功能重建,2025,20(5):293-295,310,4.基金项目
甘肃省教育厅科技创新基金项目(几丁质酶3样蛋白1水平与儿童药物难治性癫痫相关性研究,No.2022B-024) （几丁质酶3样蛋白1水平与儿童药物难治性癫痫相关性研究,No.2022B-024）
