湖南中医药大学学报2025，Vol.45Issue(5)：891-897,7.DOI:10.3969/j.issn.1674-070X.2025.05.015
探讨益气泻肺汤酊剂经皮治疗对慢性心力衰竭气虚血瘀证患者的临床疗效
Clinical efficacy of transdermal therapy of Yiqi Xiefei Decoction tincture on chronic heart failure patients with qi deficiency induced blood stasis pattern
摘要
Abstract
Objective To investigate the clinical efficacy of transdermal therapy of Yiqi Xiefei Decoction(YQXFD)tincture on chronic heart failure(CHF)patients with qi deficiency induced blood stasis pattern and its impact on their quality of life.Methods A total of 86 CHF patients with qi deficiency induced blood stasis pattern admitted to the Department of Cardiovascular Medicine of Dongzhimen Hospital,Beijing University of Chinese Medicine from January 2023 to June 2024 were divided into experimental group and control group using random number table method,with 43 patients in each group.The experimental group received conventional CHF quadruple medical therapy combined with transdermal YQXFD tincture,while the control group received conventional quadruple medical therapy combined with placebo.Both groups were treated continuously for 14 days.The levels of left ventricular ejection fraction(LVEF),plasma brain natriuretic peptide(BNP),TCM pattern scores,New York Heart Association(NYHA)Functional Classification,6-minute walk test(6MWT)results,Minnesota Living with Heart Failure Questionnaire(MLHFQ)scores,Pittsburgh Sleep Quality Index(PSQI)scores,and safety indicators were compared between the two groups before and after the treatment.Results After treatment,both groups showed significant improvements in LVEF and 6MWT compared with before treatment(P＜0.05),while significant decreases were observed in BNP levels,individual and total TCM pattern scores,PSQI scores,and total MLHFQ scores,including physical symptom scores and psychological burden scores(P＜0.05).Compared with the control group,the experimental group showed further significant improvements in LVEF and 6MWT(P＜0.05),as well as significant decreases in BNP levels,individual and total TCM pattern scores,PSQI scores,and total MLHFQ scores,including physical symptom scores and psychological burden scores(P＜0.05).After treatment,no statistically significant differences were found in NYHA scores and safety indicators between the two groups(P＞0.05).Conclusion Transdermal therapy of YQXFD tincture can effectively improve cardiac function,alleviate clinical symptoms,and enhance the quality of life of CHF patients with qi deficiency induced blood stasis pattern,with superior efficacy compared to western medicine therapy alone.关键词
益气泻肺汤/慢性心力衰竭/经皮治疗/生活质量/6分钟步行试验/明尼苏达心力衰竭生存质量量表/纽约心功能分级Key words
Yiqi Xiefei Decoction/chronic heart failure/transdermal therapy/quality of life/6-minute walk test/Min-nesota Living with Heart Failure Questionnaire/New York Heart Association Functional Classification分类
医药卫生引用本文复制引用
张昊,郝学增..探讨益气泻肺汤酊剂经皮治疗对慢性心力衰竭气虚血瘀证患者的临床疗效[J].湖南中医药大学学报,2025,45(5):891-897,7.基金项目
首都临床特色诊疗技术研究及转化应用基金项目(Z221100007422095). （Z221100007422095）
