湖南中医药大学学报2025，Vol.45Issue(5)：898-903,6.DOI:10.3969/j.issn.1674-070X.2025.05.016
养心汤联合美托洛尔对心律失常患者心功能、不良反应及氧化应激反应的影响
Effects of Yangxin Decoction combined with metoprolol on cardiac function,adverse reactions,and oxidative stress in patients with arrhythmia
摘要
Abstract
Objective To investigate the effects of Yangxin Decoction combined with metoprolol on cardiac function,adverse reactions,and oxidative stress in patients with arrhythmia.Methods A total of 80 patients with arrhythmia admitted to the Second Cardiovascular Department of the Second Hospital of Heilongjiang University of Chinese Medicine from July 2021 to July 2023 were observed.They were divided into control group and research group by the random number table method,with 40 cases in each group.The control group received Metoprolol Succinate Tablets,while the research group received Yangxin Decoction in addition to the same treatment.The TCM pattern scores,left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),clinical efficacy,serum oxidative stress factors[nitric oxide(NO),malondialdehyde(MDA)and superoxide dismutase(SOD)],myocardial injury indications[troponin Ⅰ(cTnⅠ)and creatine kinase isoenzyme(CK-MB)],heart rate,and adverse reactions were compared between the two groups.Results The effective rate of the research group was higher than that of the control group(P＜0.05),and the incidence of adverse reactions was lower than that of the control group(P＜0.05).After treatment,the LVEF,SOD levels,resting heart rate,slowest heart rate,and 24-h average heart rate of the two groups increased(P＜0.05),with higher values observed in the research group compared to the control group(P＜0.05).TCM pattern scores,LVESD,LVEDD,NO,MDA,cTnⅠ,and CK-MB levels decreased in both groups(P＜0.05),with greater reductions observed in the research group compared to the control group(P＜0.05).Conclusion Yangxin Decoction combined with metoprolol can improve cardiac function,alleviate oxidative stress response,and reduce the incidence of adverse reactions in patients with arrhythmia.关键词
心律失常/养心汤/美托洛尔/心功能/不良反应/氧化应激反应Key words
arrhythmia/Yangxin Decoction/metoprolol/cardiac function/adverse reactions/oxidative stress response分类
医药卫生引用本文复制引用
翟文姬,邓立梅,代洪绪..养心汤联合美托洛尔对心律失常患者心功能、不良反应及氧化应激反应的影响[J].湖南中医药大学学报,2025,45(5):898-903,6.基金项目
黑龙江省中医药科研项目(ZHY2023-069). （ZHY2023-069）
