湖南中医药大学学报2025，Vol.45Issue(5)：904-909,6.DOI:10.3969/j.issn.1674-070X.2025.05.017
二陈汤合六君子汤化裁联合常规西医治疗慢性阻塞性肺疾病急性加重期疗效观察
Efficacy observation of modified Erchen Decoction and Liujunzi Decoction combined with conventional western medicine therapy on acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the efficacy of modified Erchen Decoction and Liujunzi Decoction combined with conventional western medicine therapy in treating acute exacerbation of chronic obstructive pulmonary disease(AECOPD)(phlegm dampness accumulating in the lung pattern).Methods A total of 136 AECOPD patients with phlegm dampness accumulating in the lung pattern admitted to the Eighth People's Hospital of Hefei from January 2022 to January 2024 were selected and randomly divided into observation group and control group.The control group received conventional western medicine therapy,while the observation group received oral administration of modified Erchen Decoction and Liujunzi Decoction in addition to the treatment provided to the control group.Clinical efficacy,TCM pattern scores,blood gas parameters,lung function indicators,COPD Assessment Test(CAT)scores,6-minute walking distance(6MWD),serum levels of CX chemokine ligand 10(CXCL10)and CX3 chemokine ligand 1(CX3CL1)before and after treatment were compared between the two groups,and the safety of medication was analyzed as well.Results The total effective rate of the observation group was higher than that of the control group(P＜0.01).Compared with before treatment,TCM pattern scores,CAT scores,arterial partial pressure of carbon dioxide(PaCO2),and serum levels of CXCL10 and CX3CL1 decreased in both groups after treatment(P＜0.01),and the above indicators in the observation group were lower than those in the control group(P＜0.01).Compared with before treatment,both groups showed increased arterial partial pressure of oxygen(PaO2),forced expiratory volume in one second to forced vital capacity(FEV/FVC)ratio,FEV1 to the predicted value(FEV1％pred),and 6MWD after treatment(P＜0.01),and the above indicators in the observation group were higher than those in the control group(P＜0.01).During treatment,no obvious adverse events occurred in either group.Conclusion For AECOPD patients with phlegm dampness accumulating in the lung pattern,the treatment with modified Erchen Decoction and Liujunzi Decoction can relieve clinical symptoms,improve pulmonary ventilation function,enhance the quality of life,and reduce the serum levels of CXCL10 and CX3CL1,exhibiting significant efficacy and high safety.关键词
二陈汤/六君子汤/慢性阻塞性肺疾病急性加重期/痰浊阻肺证/疗效/趋化因子Key words
Erchen Decoction/Liujunzi Decoction/acute exacerbation of chronic obstructive pulmonary disease/phlegm dampness accumulating in the lung pattern/therapeutic effect/chemokine分类
医药卫生引用本文复制引用
边哨,沈珊,吴安源,王增玲..二陈汤合六君子汤化裁联合常规西医治疗慢性阻塞性肺疾病急性加重期疗效观察[J].湖南中医药大学学报,2025,45(5):904-909,6.基金项目
2022年中医药古籍文献和特色技术传承专项项目(GZY-KJS-2022-030). （GZY-KJS-2022-030）
