湖南中医药大学学报2025，Vol.45Issue(5)：910-915,6.DOI:10.3969/j.issn.1674-070X.2025.05.018
刘丽坤教授从"伏毒致痹"探析奥沙利铂所致急性周围神经毒性
Professor LIU Likun's exploration of acute oxaliplatin-induced peripheral neurotoxicity from the perspective of"latent toxicity causing impediment"
摘要
Abstract
Oxaliplatin is a third-generation platinum drug,which is widely used in digestive tract tumors,and its adverse reactions are most common in oxaliplatin-induced peripheral neurotoxicity(OIPN),which is classified into two types:acute and chronic.Acute oxaliplatin-induced peripheral neurotoxicity(AOIPN)is a transient neurotoxicity symptom occurring within 24-48 h after oxaliplatin infusion,which is dominated by sensory abnormalities that affects patients' quality of life,and in severe cases,forcing them to change their treatment regimen and affecting survival.Professor LIU Likun believes that hidden toxicity is the causative factor of AOIPN,which is characterized by impediment blocking vessels and collaterals and strong concealment,and it is treated by warming cold and dampness,expelling toxins and removing blood stasis,and the combination of external washing with the self-drafted Wenyang Tongluo Powder has a remarkable therapeutic effect.This paper discusses the treatment of AOIPN from the theory of"latent toxicity causing impediment",and attaches a clinical record in order to provide ideas for the clinical treatment of AOIPN.关键词
奥沙利铂/周围神经病变/神经毒性/伏毒/温阳通络散/名医经验Key words
oxaliplatin/peripheral neuropathy/neurotoxicity/latent toxicity/Wenyang Tongluo Powder/experience of fa-mous doctors分类
医药卫生引用本文复制引用
齐晓君,孙启蒙,李晓丽,郝守江,郝淑兰,刘丽坤..刘丽坤教授从"伏毒致痹"探析奥沙利铂所致急性周围神经毒性[J].湖南中医药大学学报,2025,45(5):910-915,6.基金项目
国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
国家中医药传承创新中心建设单位(202203) （202203）
山西省卫生健康委员会医学科技创新团队建设任务(2020TD04). （2020TD04）
