湖南中医药大学学报2025，Vol.45Issue(5)：933-938,6.DOI:10.3969/j.issn.1674-070X.2025.05.022
基于"阳微阴弦"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用
The role of vascular smooth muscle cell proliferation and migration in atherosclerosis based on the theory of"yang deficiency and yin excess"
摘要
Abstract
Atherosclerosis(AS)is a complex vascular disease characterized by lipid deposition and the accumulation of inflammatory cells within the arterial wall,often leading to adverse cardiovascular and cerebrovascular events.In recent years,vascular smooth muscle cell(VSMC)phenotypic switching,particularly the transition from the contractile to the synthetic phenotype,has been recognized as a key mechanism in AS progression.Contractile VSMCs primarily maintain vascular tone and structural stability,whereas synthetic VSMCs exhibit enhanced secretory,proliferative,and migratory capacities,thereby promoting pathological vascular remodeling.In TCM theory,the functional characteristics of contractile VSMCs can be analogized to"yang",while the biosynthetic activity of synthetic VSMCs corresponds to"yin",The dynamic transformation between these phenotypes corresponds,to a certain extent,with the TCM pathogenetic theory of"yang deficiency and yin excess".Based on this,the study integrates the TCM theory with modern cellular and molecular mechanisms to investigate the role of VSMC phenotypic switching in the AS pathogenesis.Additionally,it systematically reviews TCM therapeutic principles and methods,and the mechanisms and molecular targets of various single herbal compounds and formulas in regulating VSMC phenotypic switching and inhibiting abnormal proliferation and migration.This study aims to provide new insights for both the clinical management and fundamental research of AS while offering a unique perspective on the role of VSMCs in AS from the standpoint of TCM.关键词
动脉粥样硬化/血管平滑肌细胞/细胞增殖/细胞迁移/表型转化/阳微阴弦/胸痹心痛Key words
atherosclerosis/vascular smooth muscle cells/cell proliferation/cell migration/phenotypic switching/yang deficiency and yin excess/chest bi-impediment and cardiac pain分类
医药卫生引用本文复制引用
刘昱辛,卢婧芬,苏丹,谢雪姣..基于"阳微阴弦"理论探讨血管平滑肌细胞增殖与迁移在动脉粥样硬化中的作用[J].湖南中医药大学学报,2025,45(5):933-938,6.基金项目
国家自然科学基金项目(81603600) （81603600）
湖南省中医药科研课题重点项目(2021JJ30510) （2021JJ30510）
湖南省卫生健康委员会卫生科研课题(D202303018265) （D202303018265）
国家"基层科普行动"湖南省科普研究与实践课题(2023jckpkt034) （2023jckpkt034）
湖南省社会科学成果评审委员会一般课题(XSP2023JYZ050) （XSP2023JYZ050）
湖南省一流线上线下融合课程(2021-562) （2021-562）
湖南中医药大学研究生创新课题(2024CX103) （2024CX103）
广州中医药大学研究生国际交流与留学项目资助(2023-11-29). （2023-11-29）
