国际老年医学杂志2025，Vol.46Issue(3)：347-350,4.DOI:10.3969/j.issn.1674-7593.2025.03.016
溃疡性结肠炎致骨质疏松症的发病机制研究进展
Recent advances in understanding the pathogenesis mechanism of osteoporosis induced by ulcerative colitis
摘要
Abstract
Ulcerative colitis(UC)is a prevalent inflammatory bowel disease that is associated with multiple systemic com-plications.With the growing aging population in China,the prevalence of osteoporosis(OP)has reached the highest level worldwide.UC can lead to secondary pathological changes that disrupt skeletal homeostasis and reduce bone mineral density,thereby significantly increasing the risk of OP in affected patients.This review explores the underlying mechanisms of UC-induced OP,including micronu-trient deficiency,oxidative stress,inflammatory responses,and intestinal microbial dysbiosis.By summarizing current knowledge,this article also aims to provide a theoretical foundation for the prevention and management of OP in patients with UC.关键词
溃疡性结肠炎/骨质疏松症/发病机制/骨密度Key words
Ulcerative colitis/Osteoporosis/Pathogenesis mechanism/Bone density引用本文复制引用
刘策,杨利学,马宏忠,周昌文..溃疡性结肠炎致骨质疏松症的发病机制研究进展[J].国际老年医学杂志,2025,46(3):347-350,4.基金项目
陕西省自然科学基础研究计划(2018JM7128) （2018JM7128）
陕西省教育厅项目(2018KT-50) （2018KT-50）
咸阳市科技成果推广计划项目(18JK0210) （18JK0210）
