国际老年医学杂志2025，Vol.46Issue(3)：360-364,5.DOI:10.3969/j.issn.1674-7593.2025.03.019
黄芪活性成分调控NLRP3炎症小体延缓糖尿病肾病机制
Mechanisms of active components of Astragalus membranaceus in regulating the NLRP3 inflammasome to attenuate diabetic nephropathy
摘要
Abstract
Diabetic nephropathy(DN)is one of the most prevalent microvascular complications of diabetes mellitus(DM),characterized by progressive renal dysfunction,ultimately leading to end-stage renal disease.The"inflammatory response-fibrosis"axis plays a critical role in the progression of DN,with the NOD-like receptor thermal protein domain-associated protein 3(NLRP3)inflam-masome recognized as a key driver of this process.Understanding the interplay between inflammation,fibrosis,and NLRP3 inflamma-some activation is essential for developing effective strategies for DN prevention and treatment.Astragalus membranaceus is a widely used traditional Chinese medicine in DN management,and its active components have been shown to interfere with NLRP3 inflamma-some initiation and activation,thereby mitigating DN progression.This review highlights the pivotal role of the NLRP3 inflammasome in the"inflammatory response-fibrosis"mechanism of DN and explores the therapeutic potential of Astragalus membranaceus in targeting NLRP3 inflammasome activity.By summarizing current evidence,this article aims to provide new insights into targeted therapeutic strategies for DN.关键词
黄芪/活性成分/NOD样受体热蛋白结构域相关蛋白3/糖尿病肾病/肾间质纤维化/炎症Key words
Astragalus memeranaceus/Active component/NOD-like receptor thermal protein domain associated protein 3/Diabetic nephropathy/Renal interstitial fibrosis/Inflammatory引用本文复制引用
乔琳,高志强,郭兆安,金艳..黄芪活性成分调控NLRP3炎症小体延缓糖尿病肾病机制[J].国际老年医学杂志,2025,46(3):360-364,5.基金项目
山东省自然科学基金创新发展联合基金(ZR2022LZY005) （ZR2022LZY005）
