解剖学杂志2025，Vol.48Issue(2)：124-127,184,5.DOI:10.3969/j.issn.1001-1633.2025.02.006
推拿改善运动性疲劳大鼠肝损伤的分子机制
Molecular mechanism of Tuina to alleviate liver damage in rats with exercise-induced fatigue
王泽中 1钮妍 2国生 1沈潜 1魏培栋 1刘杨 1宋红志 1付国兵 1王康1
作者信息
- 1. 北京中医药大学东方医院推拿理疗科,北京 100078
- 2. 北京中医药大学第三附属医院推拿科,北京 100029
- 折叠
摘要
Abstract
Objective:To investigate the effects of Tuina on mitochondrial metabolism and apoptosis in the liver tissue of rats with exercise-induced fatigue,and to explore the underlying molecular mechanisms.Methods:Male Sprague-Dawley rats were selected,divided into the control group,the model group and the Tuina intervention group.Tissue injury,expression of mitochondrial metabolism-related molecules and apoptosis-related molecules in liver tissue were measured by using H-E staining,Western blotting,RT-qPCR.Results:In the model group,significant damage of mitochondrial function occurred in the liver tissue and the level of cell apoptosis markedly up-regulated.After Tuina,the mitochondrial function was significantly restored,and the level of cell apoptosis also showed a trend of alleviation.Conclusion:Tuina can effectively ameliorate exercise-induced hepatic injury in rats.This effect may be mediated by regulating mitochondrial function through the AMPK/PGC-1α signaling pathway and modulating apoptosis via the caspase-3/cytochrome C pathway.关键词
推拿/运动性疲劳/肝损伤/细胞凋亡/线粒体/功能障碍/能量代谢Key words
Tuina/exercise-induced fatigue/liver damage/cell apoptosis/mitochondrion/dysfunction/energy metabolism分类
基础医学引用本文复制引用
王泽中,钮妍,国生,沈潜,魏培栋,刘杨,宋红志,付国兵,王康..推拿改善运动性疲劳大鼠肝损伤的分子机制[J].解剖学杂志,2025,48(2):124-127,184,5.
