解剖学杂志2025，Vol.48Issue(2)：161-164,4.DOI:10.3969/j.issn.1001-1633.2025.02.013
中枢性卒中后疼痛的病理生理机制与治疗研究进展
Pathophysiological mechanism and therapeutic advances of central post-stroke pain
裴笑楠 1赵森 1臧卫东1
作者信息
- 1. 郑州大学基础医学院人体解剖学系,郑州 450001
- 折叠
摘要
Abstract
Stroke is a common neurological disorder caused by cerebrovascular events.Central post-stroke pain(CPSP)is a refractory complication of stroke characterized by variable onset times and diverse clinical manifestations.Its clinical management often yields poor therapeutic outcomes,significantly impairing patients'quality of life and even leading to suicidal tendencies in some cases.The pathogenesis of CPSP remains elusive.Current clinical treatments,including pharmacotherapy and adjunctive neuromodulatory therapies,have shown limited efficacy.This paper reviews recent advances in CPSP research from the perspectives of tissue,cellular,and molecular levels.It also discusses CPSP clinical treatment methods,aiming to provide new perspectives for both basic research and clinical management of CPSP.关键词
卒中/疼痛/信号通路/神经炎症/胶质细胞Key words
stroke/pain/signal pathway/neuroinflammation/glial cells分类
医药卫生引用本文复制引用
裴笑楠,赵森,臧卫东..中枢性卒中后疼痛的病理生理机制与治疗研究进展[J].解剖学杂志,2025,48(2):161-164,4.
