兰州大学学报（医学版）2025，Vol.51Issue(4)：75-81,7.DOI:10.13885/j.issn.1000-2812.2025.04.010
MMP-9与慢性炎症性疾病的相关性研究进展
Advances in the study of the correlation between MMP-9 and chronic inflammatory diseases
摘要
Abstract
Chronic inflammatory diseases are increasingly prevalent in clinical practice,yet they present chal-lenges such as unclear pathogenesis and poor response to treatment,leading to persistent discomfort and func-tional impairment in patients.Recent advances in understanding these conditions have highlighted the poten-tial value of inflammatory biomarkers in disease management.Matrix metalloproteinase 9(MMP-9),a pro-teolytic enzyme extensively involved in extracellular matrix(ECM)degradation and tissue remodeling,plays a pivotal role in chronic inflammatory processes across multiple organ system by mediating key pathological events including inflammatory cell infiltration,matrix decomposition and pro-inflammatory mediator release.Investigating MMP-9 provides critical insights into disease mechanisms and reveals promising therapeutic tar-gets.This review synthesized current knowledge on MMP-9's multifaceted roles and underlying molecular mechanisms in systemic chronic inflammation,aiming to inform novel diagnostic approaches and targeted treatment strategies for inflammatory disorders.关键词
基质金属蛋白酶9/慢性炎症/免疫细胞/基质金属蛋白酶组织抑制因子1/核因子κB/炎症因子Key words
matrix metalloproteinase 9/chronic inflammation/immune cell/tissue inhibitor of metalloprotein-ases 1/nuclear factor κB/inflammatory factor分类
基础医学引用本文复制引用
蒋星明,张春雷,李家豪,于畅,王勉,李佛荣,常德辉..MMP-9与慢性炎症性疾病的相关性研究进展[J].兰州大学学报（医学版）,2025,51(4):75-81,7.基金项目
甘肃省自然科学基金资助项目(22JR5RA001) （22JR5RA001）
兰州市科技课题资助项目(2023-2-63) （2023-2-63）
