老年医学与保健2025，Vol.31Issue(2)：327-334,8.
老年2型糖尿病患者血清25-羟维生素D水平与葡萄糖目标范围内时间的相关性研究
A study on correlation between serum 25-hydroxyvitamin D level and time in target range of glucose in elderly patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the correlation between serum 25-hydroxyvitamin D[25(OH)D]level and the time in range(TIR)of glucose in elderly patients with type 2 diabetes mellitus(T2DM).Methods A total of 208 elderly T2DM patients treated in Department of Endocrinology,Jinling Clinical Medical College of Nanjing Medical University from April 2017 to February 2022 were enrolled.All of them underwent 3-day continuous glucose monitoring(CGM)and serum 25(OH)D measurement.TIR and glycemic variability(GV)parameters were assessed via CGM.Based on the tertile cut-off points of serum 25(OH)D levels,the patients were divided into three groups:G1 group[25(OH)D level＜21.19 ng/mL],G2 group[21.19 ng/mL≤25(OH)D level＜25.52 ng/mL],and G3 group[25(OH)D leve1≥ 25.52 ng/mL].In addition,each subject underwent standardized 100 g steamed bread meal test to evaluate the secretory function of pancreatic beta cells.Results The G3 group exhibited significantly higher TIR compared to G1 group and G2 group(P＜0.05).The correlation analysis results showed that serum 25(OH)D level was significantly positively correlated with TIR and time in tight range,but was negatively correlated with time above range(TAR)of glucose,GV index and glycated hemoglobin A1c(HbA1c).Serum 25(OH)D level was also positively correlated with the early insulin secretion index,the area under the C-peptide curve within 30 min,and the area under the C-peptide curve within 180 min.The Fisher's r-to-z test results showed that the correlation between serum 25(OH)D level and TIR(r=0.352,P＜0.001)was slightly stronger than its correlation with HbA1c(r=-0.313,P＜0.001)and mean amplitude of glycemic excursions(r=-0.166,P＜0.001).Multiple stepwise linear regression analysis indicated that serum 25(OH)D level was an independent influencing factor for TIR,TAR and HOMA-β.Conclusion Lower serum 25(OH)D levels may play a potential role in the imbalance of blood glucose homeostasis and impaired pancreatic β-cell secretion function in elderly T2DM patients.关键词
老年/维生素D/2型糖尿病/葡萄糖目标范围内时间/持续血糖监测/胰岛素抵抗/胰岛β细胞功能Key words
elderly/vitamin D/type 2 diabetes mellitus/time in target range of glucose/continuous glucose monito-ring/insulin resistance/pancreatic β-cell function引用本文复制引用
姜雯雯,王魏,梁悦,柏晓勇,梁菁菁,卢斌,邵加庆..老年2型糖尿病患者血清25-羟维生素D水平与葡萄糖目标范围内时间的相关性研究[J].老年医学与保健,2025,31(2):327-334,8.基金项目
国家自然科学基金资助项目(82470885) （82470885）
江苏省卫生健康委科研项目(ZD2022037) （ZD2022037）
