老年医学与保健2025，Vol.31Issue(2)：340-344,5.
康柏西普玻璃体腔注射联合PRP治疗老年增殖性糖尿病视网膜病变疗效及对房水VEGF、视力水平和术后并发症的影响
Efficacy of intravitreal injection of conbercept combined with PRP in treatment of elderly patients with proliferative diabetic retinopathy and its influence on aqueous humor VEGF,visual acuity and postoperative complications
摘要
Abstract
Objective To investigate the efficacy of intravitreal injection of conbercept combined with panretinal photo-coagulation(PRP)in the treatment of elderly patients with proliferative diabetic retinopathy(PDR)and its influence on aqueous humor vascular endothelial growth factor(VEGF),visual acuity and postoperative complications,and provide a meth-od for the treatment of this disease.Methods The clinical data of 366 elderly PDR patients(366 eyes)admitted to Third People's Hospital of Chengdu City from January 2022 to January 2024 were retrospectively analyzed.They were divided into PRP group and injection group according to different treatment regimens,with 183 cases in each group.Both groups received PRP treatment.The injection group received 0.05 mL intravitreal injection of conbercept at 72 h before the first PRP.The clini-cal efficacy at 3 months after the end of the surgery was compared between the two groups.The best corrected visual acuity(BCVA),central macular thickness(CMT)and intraocular pressure(IOP)before surgery and at 1 month and 3 months after surgery,aqueous humor biochemical indexes[VEGF,stromal cell derived factor 1(SDF-1)]at 3 months after surgery and postoperative complications were compared between the two groups.Results The efficacy in the injection group was signifi-cantly higher than that in the PRP group(89.62％ vs 81.97％,P＜0.05).There were statistically significant differences in BCVA between the two groups in terms of time,grouping,and interaction(P＜0.05).At 1 and 3 months after surgery,the BCVA in the injection group was significantly lower than that in the PRP group(P＜0.05).There were statistically significant differences in CMT between the two groups in terms of time,grouping,and interaction(P＜0.05).At 1 and 3 months after surgery,CMT in the injection group was significantly lower than that in the PRP group(P＜0.05).There were statistically significant differences in IOP between the two groups in terms of time and grouping(P＜0.05).At 1 month and 3 months after surgery,IOP in both groups decreased significantly compared with that before surgery(P＜0.05),but there was no statistically significant difference between the two groups(P＞0.05).At 3 months after surgery,the levels of VEGF and SDF-1 in the aqueous humor in the injection group were significantly lower than those in the PRP group(P＜0.05).There was no statisti-cally significant difference in the incidence of complications between the injection group(19.67％)and the PRP group(12.57％)(P＞0.05).Conclusion Intra vitreal injection of conbercept combined with PRP can effectively treat elderly PDR patients,improve their visual acuity,reduce CMT,and improve the aqueous humor microenvironment.It is safe and effective and has certain clinical application value.关键词
老年/增殖性糖尿病视网膜病变/康柏西普/全视网膜光凝术/视力水平/房水/血管内皮生长因子Key words
elderly/proliferative diabetic retinopathy/conbercept/panretinal photocoagulation/visual acuity level/aqueous humor/vascular endothelial growth factor引用本文复制引用
程玲,朱敬,王爽,余雨林..康柏西普玻璃体腔注射联合PRP治疗老年增殖性糖尿病视网膜病变疗效及对房水VEGF、视力水平和术后并发症的影响[J].老年医学与保健,2025,31(2):340-344,5.基金项目
四川省自然科学基金项目(青年科学基金项目)(2022NSFSC1400) （青年科学基金项目）
