检验医学与临床2025，Vol.22Issue(10)：1297-1300,1306,5.DOI:10.3969/j.issn.1672-9455.2025.10.001
吡拉西坦注射液联合阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能及血清miR-124水平的影响
Effect of piracetam injection combined with alteplase intravenous thrombolysis on neurological function and serum miR-124 level in patients with acute cerebral infarction
摘要
Abstract
Objective To investigate the effect of piracetam injection combined with alteplase intravenous thrombolysis on neurological function and serum microRNA-124(miR-124)level in patients with acute cere-bral infarction.Methods A total of 96 patients with acute cerebral infarction admitted to the Eighth People's Hospital of Hefei in Anhui Province from November 2021 to January 2024 were selected as the research ob-jects.All the research objects were divided into control group and observation group by dynamic random method,with 48 cases in each group.The control group was treated with alteplase intravenous thrombolysis on the basis of conventional treatment.The observation group was treated with piracetam injection combined with alteplase intravenous thrombolysis on the basis of routine treatment.The clinical efficacy,National Insti-tutes of Health Stroke Scale(NIHSS)score,serum miR-124,fibrinogen(FIB),D-dimer(D-D),nitric oxide(NO),endothelin-1(ET-1),and thromboxane 2(TXB2)levels were compared between the two groups before and after treatment.Results The total effective rate of the observation group was higher than that of the con-trol group,and the difference was statistically significant(x2=4.718,P=0.039).After treatment,the NIHSS score,ET-1,TXB2,miR-124,FIB and D-D levels of the two groups were lower than those before treatment,and the NO level was higher than that before treatment,and the differences were statistically significant(P＜0.05).After treatment,the NIHSS score and the levels of ET-1,TXB2,miR-124,FIB and D-D in the observa-tion group were lower than those in the control group,and the level of NO was higher than that in the control group,and the differences were statistically significant(P＜0.05).Conclusion Piracetam injection combined with alteplase intravenous thrombolysis can effectively improve the neurological function and vascular endo-thelial function of patients with acute cerebral infarction,reduce the level of serum miR-124,the curative effect is exact,it is worthy of clinical application.关键词
吡拉西坦注射液/阿替普酶静脉溶栓/急性脑梗死/神经功能/微小RNA-124Key words
piracetam injection/intravenous thrombolysis with alteplase/acute cerebral infarction/neurological function/microRNA-124分类
临床医学引用本文复制引用
吴舒梅,李彬,李雪婷..吡拉西坦注射液联合阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能及血清miR-124水平的影响[J].检验医学与临床,2025,22(10):1297-1300,1306,5.基金项目
安徽省卫生计生委科研计划项目(2018SEYL012). （2018SEYL012）
