检验医学与临床2025，Vol.22Issue(10)：1301-1306,6.DOI:10.3969/j.issn.1672-9455.2025.10.002
血清Semaphorin7A、CXCL12、syndecan-4对慢性心力衰竭的诊断价值
Diagnostic value of serum Semaphorin7A,CXCL12 and syndecan-4 in chronic heart failure
摘要
Abstract
Objective To investigate the diagnostic value of serum Semaphorin7A(SEMA7A),chemokine ligand 12(CXCL12)and syndecan-4 in chronic heart failure(CHF).Methods A total of 138 CHF patients admitted to the Affiliated Hospital of Hubei Three Gorges Vocational and Technical College from September 2022 to January 2023 were selected as the observation group.Another 138 healthy people who underwent physical examination in the Affiliated Hospital of Hubei Three Gorges Vocational and Technical College dur-ing the same period were selected as the control group.According to the New York Heart Association cardiac function classification,all CHF patients were divided into Ⅱ,Ⅲ and Ⅳ grades.The serum levels of SEMA7A,CXCL12 and syndecan-4 were compared between the two groups.Spearman correlation analysis was used to analyze the correlation between serum SEMA7A,CXCL12,syndecan-4 levels and cardiac function classification in CHF patients.Multivariate Logistic regression was used to analyze the influencing factors of CHF.The re-ceiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum SEMA7A,CX-CL12 and syndecan-4 alone and in combination for CHF.Results The systolic blood pressure,diastolic blood pressure,serum SEMA7A,CXCL12 and syndecan-4 levels in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were 32 patients with grade Ⅱ,48 patients with grade Ⅲ,and 58 patients with grade Ⅳ.The serum levels of SEMA7A,CXCL12 and syndecan-4 in patients with grade Ⅳ and Ⅲ were higher than those in patients with grade Ⅱ,and the serum levels of SEMA7A,CXCL12 and syndecan-4 in patients with grade Ⅳ were higher than those in patients with grade Ⅲ,and the differences were statistically significant(P＜0.05).Spearman correlation analysis showed that serum SEMA7A,CXCL12 and syndecan-4 levels were positively correlated with cardiac function classifi-cation in CHF patients(r=0.485,0.676,0.522,all P＜0.05).Multivariate Logistic regression analysis showed that SEMA7A,CXCL12 and syndecan-4 were influencing factors for CHF(P＜0.05).ROC curve a-nalysis showed that the area under the curve(AUC)of serum SEMA7A,CXCL12 and syndecan-4 in the diag-nosis of CHF were 0.745,0.765 and 0.836 respectively,and the AUC of combined diagnosis of the three was 0.923,larger than the AUC of each index alone(Zthree-combination-SEMA7A=6.032,Zthree-combination-CXCL12=5.419,Zthree-combination-syndecan-4=4.215,Pthree-combination-SEMA7A＜0.05,Pthree-combination-CXCL12＜0.05,Pthree-combination-syndecan-4＜0.05).Con-clusion The serum levels of SEMA7A,CXCL12 and syndecan-4 in CHF patients are significantly increased,and they are all influencing factors of CHF.The combined detection of the three has high diagnostic value for CHF and can be widely used in clinical diagnosis.关键词
慢性心力衰竭/Semaphorin7A/趋化因子12/多配体蛋白聚糖-4/诊断价值Key words
chronic heart failure/Semaphorin7A/chemokine ligand 12/syndecan-4/diagnostic value分类
临床医学引用本文复制引用
谢辉,虞春宜,蔡永芳,宋微,许德俊,向昌光子,廖修燕,祝鹏..血清Semaphorin7A、CXCL12、syndecan-4对慢性心力衰竭的诊断价值[J].检验医学与临床,2025,22(10):1301-1306,6.基金项目
湖北省卫生健康委员会科研项目(WJ2019M147). （WJ2019M147）
