临床小儿外科杂志2025，Vol.24Issue(4)：301-306,6.DOI:10.3760/cma.j.cn101785-202412060-001
儿童Ⅰ型神经纤维瘤病脊柱侧弯的诊治要点
Clinical diagnostics and interventions of children with neurofibromatosis type 1 associated scoliosis
摘要
Abstract
Children of type 1 neurofibromatosis may present with a wide range of symptoms,including café au lait spots,plexiform neurofibromas and skeletal system deformities.Among them,scoliosis is the most common skeletal deformity.Children with NF1 scoliosis often have nutritional deficiency-type changes in spinal bones,leading to early onset and rapid progression of scoliosis,causing deformity of appearance and affecting normal growth and development of spine.Thus early intervention is necessary.Based on the location,type,de-gree of scoliosis,and patient age and growth potential,appropriate treatments may be selected.In addition to treating scoliosis,attention should also be paid to managing concomitant deformities and preventing complica-tions.For overall management of NF1,multidisciplinary treatment is needed to provide standardized,individual-ized and meticulous treatment.关键词
Ⅰ型神经纤维瘤病/脊柱侧弯/诊断/外科手术/保守治疗/药物疗法/多学科诊治/儿童Key words
Neurofibromatosis Type 1/Scoliosis/Diagnosis/Surgical Procedures,Operative/Conser-vative Treatment/Drug Therapy/Multi-disciplinary Team/Child引用本文复制引用
曹隽,李海艟..儿童Ⅰ型神经纤维瘤病脊柱侧弯的诊治要点[J].临床小儿外科杂志,2025,24(4):301-306,6.基金项目
北京市自然科学基金-海淀原始创新联合基金资助项目(L222095) （L222095）
国家重点研发计划资助(2023YFC2507701) Beijing Natural Science Foundation(L222095) （2023YFC2507701）
National Key R&D Program of China(2023YFC2507701) （2023YFC2507701）
