检验医学与临床2025，Vol.22Issue(10)：1307-1310,1316,5.DOI:10.3969/j.issn.1672-9455.2025.10.003
血管内治疗联合静脉溶栓治疗对大血管闭塞性AIS患者血清VE-cadherin、MCP-1水平及疗效的影响
Effect of endovascular therapy combined with intravenous thrombolytic therapy on serum VE-cadherin and MCP-1 levels and efficacy in patients with large vessel occlusive AIS
摘要
Abstract
Objective To analyze the effect of endovascular therapy combined with intravenous thrombo-lytic therapy on the levels of vascular endothelial cadherin(VE-cadherin)and monocyte chemoattractant pro-tein-1(MCP-1)and its efficacy in patients with acute ischemic stroke with large vessel occlusion(LVO-AIS).Methods A total of 80 patients with LVO-AIS diagnosed and treated in the hospital from December 2020 to December 2022 were retrospectively selected as the research objects.According to different treatment meth-ods,the patients were divided into intravenous thrombolytic therapy group(control group)and endovascular therapy combined with intravenous thrombolytic therapy group(study group),with 40 cases in each group.The control group was treated with intravenous thrombolytic therapy,and the study group was treated with endovascular therapy on the basis of the control group.VE-cadherin,MCP-1,neurological function,cerebral infarction volume,prognosis,vascular recanalization and complications were compared between the two groups before and after treatment.Results There was no significant difference in the levels of VE-cadherin and MCP-1,National Insti-tutes of Health Stroke Scale(NIHSS)score,modified Rankin scale(mRS)score,and stroke volume between the two groups before treatment(P＞0.05).After treatment,the levels of VE-cadherin and MCP-1,NIHSS score and mRS score of the two groups were lower than those before treatment,and the stroke volume was smaller than that before treatment,and the study group was lower/less than the control group,and the differ-ences were statistically significant(P＜0.05).After treatment,the recanalization rate of blood vessels in the study group was 90.00％,which was higher than 72.50％in the control group,and the difference was statisti-cally significant(P＜0.05).The total incidence of complications in the study group was 7.50％,which was lower than 30.00％in the control group,and the difference was statistically significant(x2=6.646,P=0.010).Conclusion Endovascular therapy combined with intravenous thrombolytic therapy can effectively re-duce serum VE-cadherin and MCP-1,alleviate neurological deficits,improve prognosis,increase vascular reca-nalization rate and reduce the incidence of complications in patients with LVO-AIS.关键词
急性缺血性脑卒中/静脉溶栓治疗/血管内治疗/脑血流/神经功能Key words
acute ischemic stroke/intravenous thrombolytic therapy/endovascular therapy/cerebral blood flow/neurological function分类
临床医学引用本文复制引用
黄惠英,谢孟桥,杜红,张珊..血管内治疗联合静脉溶栓治疗对大血管闭塞性AIS患者血清VE-cadherin、MCP-1水平及疗效的影响[J].检验医学与临床,2025,22(10):1307-1310,1316,5.基金项目
中国脑卒中高危人群干预适宜技术研究及推广项目(GN-2018R0011). （GN-2018R0011）
