检验医学与临床2025，Vol.22Issue(10)：1311-1316,6.DOI:10.3969/j.issn.1672-9455.2025.10.004
血清PSGL-1、presepsin、MIP-1α对老年冠心病冠状动脉搭桥术后发生肺部感染的诊断价值
Diagnostic value of serum PSGL-1,presepsin and MIP-1α for pulmonary infection after coronary artery bypass grafting in elderly patients with coronary heart disease
摘要
Abstract
Objective To investigate the diagnostic value of serum P-selectin glycoprotein ligand(PSGL-1),leukocyte differentiation antigen 14 subtype(presepsin)and macrophage inflammatory protein-1α(MIP-1α)for pulmonary infection in elderly patients with coronary heart disease after coronary artery bypass graft-ing.Methods A total of 147 elderly patients with coronary heart disease who underwent coronary artery by-pass grafting in the hospital from September 2022 to September 2023 were selected as the research objects.According to whether pulmonary infection occurred during hospitalization after coronary artery bypass graft-ing,all subjects were divided into occurrence group(69 cases)and non-occurrence group(78 cases).The ser-um levels of PSGL-1,presepsin and MIP-1α were detected by enzyme-linked immunosorbent assay.Multivari-ate Logistic regression was used to analyze the influencing factors of postoperative pulmonary infection after coronary artery bypass grafting in elderly patients with coronary heart disease.Receiver operating characteris-tic(ROC)curve was used to analyze the diagnostic value of serum PSGL-1,presepsin and MIP-1α alone and in combination for postoperative pulmonary infection after coronary artery bypass grafting in elderly patients with coronary heart disease.Results Compared with the non-occurrence group,the occurrence group had a significantly higher proportion of patients with cardiopulmonary bypass,a significantly higher proportion of patients with a history of diabetes,and significantly higher serum levels of PSGL-1,presepsin,and MIP-1α(P＜0.05),a significantly lower left ventricular ejection fraction(LVEF),and a significantly longer ventilator ventilation time(P＜0.05).Multivariate Logistic regression analysis showed that ventilator ventilation time,LVEF,PSGL-1,presepsin,history of diabetes and MIP-1α were all influencing factors for postoperative pul-monary infection after coronary artery bypass grafting in elderly patients with coronary heart disease(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum PSGL-1,presepsin,MIP-1αand the combination of the three for the diagnosis of postoperative pulmonary infection after coronary artery bypass grafting in elderly patients with coronary heart disease were 0.812,0.844,0.838,0.919 respectively.The AUC of the combined detection of the three was greater than that of each individual diagnosis(Zcombined-PSGL-1=3.198,Zcombined-presepsin=2.326,Zcombined-MIP-1α=3.161,Zcombined--PSGL-1=3.198,Zcombined-Presepsin=2.326,Zcombined-MIP-1α=3.161,Pcombined-PSGL-1=0.001,Pcombined-Presepsin=0.020,Pcombined-MIP-1α=0.002).Conclusion The levels of PSGL-1,presepsin and MIP-1α are significantly increased in the serum of elderly patients with pulmonary infection after coronary artery bypass grafting.The combined detection of the three has high diagnostic value for pulmonary infection after coronary artery bypass grafting in elderly patients with coronary heart disease.关键词
P-选择素糖蛋白配体/白细胞分化抗原14亚型/巨噬细胞炎性蛋白-1α/冠心病/冠状动脉搭桥术Key words
P-selectin glycoprotein ligand/leukocyte differentiation antigen 14 subtype/macrophage inflammatory protein-1α/coronary heart disease/coronary artery bypass grafting分类
临床医学引用本文复制引用
李锐,李良,杨健,郭海平..血清PSGL-1、presepsin、MIP-1α对老年冠心病冠状动脉搭桥术后发生肺部感染的诊断价值[J].检验医学与临床,2025,22(10):1311-1316,6.基金项目
河北省重点研发计划项目(20377752D). （20377752D）
