检验医学与临床2025，Vol.22Issue(10)：1317-1322,6.DOI:10.3969/j.issn.1672-9455.2025.10.005
重症肺炎患者血清涎液化糖链抗原-6、癌易感性候选基因9水平与病情严重程度及预后的关系
Relationship between serum levels of saliva liquefied sugar chain antigen-6 and cancer susceptibility candidate gene 9 and disease severity and prognosis in patients with severe pneumonia
摘要
Abstract
Objective To explore the relationship between the levels of serum saliva liquefied sugar chain antigen-6(KL-6)and cancer susceptibility candidate gene 9(CASC9)in patients with severe pneumonia(SP)and the severity of the disease as well as prognosis.Methods A total of 107 SP patients admitted to the hospi-tal from January 2021 to December 2023 were selected as the SP group.According to the acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)score,the SP group was divided into low risk group(27 cases),medium risk group(44 cases)and high risk group(36 cases).According to the 28 d prognosis,the SP group was divided into death group and survival group.In addition,55 healthy people who underwent physical exami-nation in the hospital during the same period were selected as the control group.Enzyme-linked immunosor-bent assay and real-time fluorescence quantitative polymerase chain reaction were used to detect the serum levels of KL-6 and CASC9.Spearman correlation analysis was used to analyze the correlation between serum KL-6 and CASC9 levels and the severity of SP patients.Multivariate Logistic regression was used to analyze the influencing factors of death in SP patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum KL-6 and CASC9 alone and combined detection for the death of SP pa-tients.Results The serum KL-6 level of the SP group was higher than that of the control group,and the CASC9 level was lower than that of the control group,and the differences were statistically significant(P＜0.05).The levels of KL-6 in the low risk group,the medium risk group and the high risk group were increased in turn,and the levels of CASC9 were decreased in turn,and the differences were statistically significant(P＜0.05).Spearman correlation analysis showed that serum KL-6 level in SP patients was positively correlated with the severity of the disease(rs=0.778,P＜0.001),and serum CASC9 level was negatively correlated with the severity of the disease(rs=-0.761,P＜0.001).After 28 d of follow-up,the success rate was 100％.There were 36 cases in the death group,with a mortality rate of 33.64％(36/107),and 71 cases in the survival group.There were significant differences in disease severity,KL-6 and CASC9 levels between the death group and the survival group(P＜0.05).Multivariate Logistic regression analysis showed that medium and high risk of disease severity and increased KL-6 level were risk factors for death in SP patients(P＜0.05),and increased CASC9 level was a protective factor for death in SP patients(P＜0.05).The results of ROC curve analysis showed that the area under the curve of serum KL-6 combined with CASC9 to predict the death of SP patients was 0.923,which was larger than 0.804 and 0.796 predicted by serum KL-6 and CASC9 alone(Z=2.904,3.290,P=0.004,0.001).Conclusion The increase of serum KL-6 level and the decrease of CASC9 level in SP patients are closely related to the severity of the disease and death.The combination of ser-um KL-6 and CASC9 has a high value in predicting the death of SP patients.关键词
重症肺炎/涎液化糖链抗原-6/癌易感性候选基因9/病情严重程度/预后Key words
severe pneumonia/saliva liquefied sugar chain antigen-6/cancer susceptibility candidate gene 9/severity of disease/prognosis分类
临床医学引用本文复制引用
王锐昊,王珏,王凯封..重症肺炎患者血清涎液化糖链抗原-6、癌易感性候选基因9水平与病情严重程度及预后的关系[J].检验医学与临床,2025,22(10):1317-1322,6.基金项目
黑龙江省卫生健康委科研课题(2020060). （2020060）
