检验医学与临床2025，Vol.22Issue(10)：1323-1327,1333,6.DOI:10.3969/j.issn.1672-9455.2025.10.006
突发性耳聋患者血清VEGF、VCAM-1水平与病情严重程度和预后不良的关系
Relationship between serum VEGF and VCAM-1 levels and disease severity and poor prognosis in patients with sudden deafness
摘要
Abstract
Objective To investigate the relationship between serum vascular endothelial growth factor(VEGF)and vascular cell adhesion molecule-1(VCAM-1)levels and disease severity and poor prognosis in patients with sudden deafness(SD).Methods A total of 100 SD patients admitted to the hospital from Janu-ary to July 2024 were selected as the study group,and 50 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.According to the severity of the dis-ease,the SD patients were divided into mild group,moderate group,severe group and very severe group.Ac-cording to the results of pure tone audiometry,SD patients were divided into low frequency descent type,high frequency descent type,flat descent type and total deafness type.According to the clinical efficacy,SD patients were divided into good prognosis group and poor prognosis group.The levels of VEGF and VCAM-1 in all subjects were detected by enzyme-linked immunosorbent assay.Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in SD patients.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum VEGF and VCAM-1 alone and combined detection for poor prognosis in SD patients.Results The levels of serum VEGF and VCAM-1 in the study group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were 19 cases in the mild group,43 cases in the moderate group,26 cases in the severe group,and 12 cases in the very severe group.The serum levels of VEGF and VCAM-1 in the mild group,moderate group,severe group and very severe group were increased in turn,and the differences between any two groups were statisti-cally significant(P＜0.05).There were 44 cases of low frequency descent type,28 cases of high frequency de-scent type,17 cases of flat descent type,and 11 cases of total deafness.The serum VEGF and VCAM-1 levels of the low frequency descent type,the high frequency descent type,the flat descent type and the total deafness type were increased in turn,and the differences between any two groups were statistically significant(P＜0.05).There were 61 patients in the good prognosis group and 39 patients in the poor prognosis group.The age of the poor prognosis group was older than that of the good prognosis group,and the serum levels of VEGF and VCAM-1 were higher than those of the good prognosis group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that increased age,increased VEGF level and increased VCAM-1 level were risk factors for poor prognosis in SD patients(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum VEGF for predicting poor prognosis of SD pa-tients was 0.794,the AUC of serum VCAM-1 for predicting poor prognosis of SD patients was 0.828,and the AUC of serum VEGF and VCAM-1 for predicting poor prognosis of SD patients was 0.871.The AUC of combined detection of the two markers in predicting poor prognosis of SD patients was greater than that of single detection(Z=2.542,2.624,P＜0.05).Conclusion The serum levels of VEGF and VCAM-1 in SD pa-tients are significantly increased,which are related to the severity and poor prognosis of patients.Combined detection can effectively improve the predictive value for poor prognosis of patients.关键词
血管内皮生长因子/血管细胞黏附分子-1/突发性耳聋/病情严重程度/预后Key words
vascular endothelial growth factor/vascular cell adhesion molecule-1/sudden deafness/severity of disease/prognosis分类
临床医学引用本文复制引用
薛茜,李志强,王金渊,刘美畅,张竞莹..突发性耳聋患者血清VEGF、VCAM-1水平与病情严重程度和预后不良的关系[J].检验医学与临床,2025,22(10):1323-1327,1333,6.基金项目
中国金属学会冶金安全与健康分会健康卫生科研项目(jkws202352). （jkws202352）
