检验医学与临床2025，Vol.22Issue(10)：1350-1354,5.DOI:10.3969/j.issn.1672-9455.2025.10.011
血清ApoE、CRABP2及S100A2对子宫内膜癌的诊断价值
Diagnostic Value of Serum ApoE,CRABP2,and S100A2 in Endometrial Carcinoma
摘要
Abstract
Objective To investigate the diagnostic value of serum apolipoprotein E(ApoE),cellular retino-ic acid-binding protein 2(CRABP2),and S100 calcium-binding protein A2(S100A2)in endometrial carcinoma(EC).Methods A total of 108 EC patients admitted to the Affiliated Hospital of Inner Mongolia Medical U-niversity from June 2018 to November 2020 were selected as the EC group,and 108 healthy volunteers who underwent physical examination in the Affiliated Hospital of Inner Mongolia Medical University during the same period were selected as the control group.The clinical data of all research objects were collected.The se-rum levels of ApoE,CRABP2 and S100A2 were detected in all subjects.According to the follow-up results,EC patients with recurrence,metastasis and death due to cancer were included in the poor prognosis group,and the rest were included in the good prognosis group.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum ApoE,CRABP2 and S100A2 alone and combined detection for EC and the predictive value of poor prognosis of EC patients.Results The serum levels of ApoE,CRABP2 and S100A2 in EC group were higher than those in control group,and the differences were statistically signifi-cant(P＜0.05).The levels of serum ApoE,CRABP2 and S100A2 in EC patients with lymph node metastasis,FIGO stage Ⅲ—Ⅳ,low degree of differentiation,diffuse lesion type,and myometrial invasion depth ≥1/2 were all elevated(P＜0.05).The follow-up rate of the included patients was 100％.Among them,27 EC pa-tients with recurrence,metastasis and cancer death were included in the poor prognosis group,and the remai-ning 81 were included in the good prognosis group.The levels of serum ApoE,CRABP2 and S100A2 in the good prognosis group were lower than those in the poor prognosis group,and the differences were statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum ApoE,CRABP2 and S100A2 for the diagnosis of EC were 0.710(95％CI:0.644-0.769),0.793(95％CI:0.733-0.845)and 0.768(95％CI:0.706-0.823)respectively,and the AUC of combined diagnosis of EC was 0.854(95％CI:0.800-0.898).The AUC of combined diagnosis of EC was greater than that of individual diagnosis(Zcombined with ApoE=4.08 2,Zcombined with CRABP2=2.049,Zcombined with S100A2=2.901,P＜0.05).The AUC of serum ApoE,CRABP2 and S100A2 detection alone in predicting poor prognosis of EC patients were 0.862(95％CI:0.783-0.921),0.875(95％CI:0.798-0.931)and 0.839(95％CI:0.756-0.903)respectively.The AUC of the combined detection of the three for predicting poor prognosis of EC patients was 0.963(95％CI:0.908-0.990).The AUC of the combined detection of the three factors for predicting poor prognosis of EC patients was greater than that of single prediction(Zthree-combination-ApoE=2.042,Zthree-combination-CRABP2=2.448,Zthree-combination-S100A2=2.413,P＜0.05).Conclusion Serum ApoE,CRABP2,and S100A2 levels are significantly elevated in EC patients.The combined detection of these markers demonstrates substantial value in the diag-nosis of EC and poor prognosis.关键词
子宫内膜癌/载脂蛋白E/细胞视黄酸结合蛋白2/S100钙结合蛋白A2/诊断/预后Key words
endometrial carcinoma/apolipoprotein E/cellular retinoic acid-binding protein 2/S100 calcium-binding protein A2/diagnosis/prognosis分类
临床医学引用本文复制引用
塔娜,任晓玉,于聪祥,索静..血清ApoE、CRABP2及S100A2对子宫内膜癌的诊断价值[J].检验医学与临床,2025,22(10):1350-1354,5.基金项目
内蒙古自治区自然科学基金项目(2022QN08026). （2022QN08026）
