检验医学与临床2025，Vol.22Issue(10)：1361-1367,7.DOI:10.3969/j.issn.1672-9455.2025.10.013
血清Eotaxin、Thioredoxin、sST2与伴冲动暴力行为的精神分裂症患者认知功能损害的关系
Relationship between serum Eotaxin,Thioredoxin,sST2 and cognitive impairment in schizophrenia patients with impulsive violent behavior
摘要
Abstract
Objective To explore the relationship between serum eosinophil chemokine(Eotaxin),thiore-doxin(Trx),soluble ST2 protein(sST2)and cognitive impairment in schizophrenia patients with impulsive violent behavior,and to construct a nomogram prediction model for the risk of cognitive impairment.Methods A total of 170 schizophrenia patients with impulsive violence admitted to the Panzhihua Third Peo-ple's Hospital from September 2021 to September 2023 were prospectively selected as the impulsive violence group,and 100 healthy subjects in the Panzhihua Third People's Hospital were selected as the control group.The serum Eotaxin,Trx and sST2 levels were compared between impulsive violence group and control group.According to the Chinese Cognitive Ability Scale,the impulsive violence group was divided into cognitive im-pairment group and non-cognitive impairment group.Multivariate Logistic regression was used to analyze the influencing factors of cognitive impairment in schizophrenia patients with impulsive violent behavior.The re-ceiver operating characteristic(ROC)curve was used to analyze the predictive efficacy of serum Eotaxin,Trx and sST2 for cognitive impairment in schizophrenia patients with impulsive violent behavior.Results The levels of Eotaxin,Trx and sST2 in the impulsive violence group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were 99 cases in the cognitive impairment group and 71 cases in the non-cognitive impairment group.There were significant differences in the number of hospitalizations,education level,Social Disability Screening Scale(SDSS)score,Postive and Negative Syn-drome Scale(PANSS)negative symptoms score,serum Trx,Eotaxin and sST2 levels between the cognitive impairment group and the non-cognitive impairment group(P＜0.05).Multivariate Logistic regression analy-sis showed that increased negative symptom score of PANSS,education level of primary school or below,in-creased serum Eotaxin level,increased Trx level,increased sST2 level,≥2 times of hospitalization,and in-creased SDSS score were independent risk factors for cognitive impairment in schizophrenia patients with im-pulsive violent behavior(P＜0.05).ROC curve and nomogram model analysis results showed that the area under the curve(AUC)of serum Eotaxin,Trx,sST2 and the nomogram model for predicting cognitive im-pairment in patients with schizophrenia were 0.766(95％CI:0.686-0.846),0.806(95％CI:0.732-0.880),0.868(95％CI:0.809-0.926),0.986(95％CI:0.971-1.000)respectively.The prediction efficiency of the nomogram model was significantly better than that of each index alone.Conclusion The number of hospitali-zation ≥2 times,the education levels was primary school and below,increased SDSS score,increased PANSS negative symptom score,increased serum Eotaxin level,increased Trx level and increased sST2 level are inde-pendent risk factors for cognitive impairment in schizophrenia patients with impulsive violent behavior.The constructed nomogram prediction model has a high predictive value for cognitive impairment.关键词
精神分裂症/冲动暴力行为/嗜酸性粒细胞趋化因子/可溶性ST2蛋白/认知功能Key words
schizophrenia/impulsive violent behavior/eosinophil chemokine/soluble ST2 protein/cognitive impairment分类
医药卫生引用本文复制引用
杨玲,尹继续,陈钰,杨远莲,杨娅玲,陆兰..血清Eotaxin、Thioredoxin、sST2与伴冲动暴力行为的精神分裂症患者认知功能损害的关系[J].检验医学与临床,2025,22(10):1361-1367,7.基金项目
四川省卫生健康委员会科研课题(普及应用项目,20PJ0276). （普及应用项目,20PJ0276）
