老年医学与保健2025，Vol.31Issue(2)：438-442,5.
瑞马唑仑联合瑞芬太尼用于老年心功能不全患者的镇静镇痛的效果研究
Effects of remimazolam combined with remifentanil on sedation and analgesia in elderly patients with cardiac insufficiency
摘要
Abstract
Objective To investigate the sedative and analgesic effects of remimazolam combined with remifentanil on elderly patients with cardiac insufficiency in Intensive Care Unit.Methods A total of 196 elderly patients with cardiac insuffi-ciency who received ventilator-assisted breathing and admitted to Second People's Hospital of Meishan City from December 2022 to December 2023 were selected.According to the different sedation and analgesia regimens adopted,they were divided into two groups:propofol group(109 cases,adopted the sedation and analgesia regimen of propofol combined with remifen-tanil)and remimazolam group(87 cases,adopted the sedation and analgesia regimen of remimazolam combined with remifen-tanil).The shallow sedation compliance time and compliance rate,hemodynamic monitoring indicators,mechanical ventilation time and hospitalization time of the two groups were compared.Results The shallow sedation compliance time in the remima-zolam group was faster than that in the propofol group[(23.4±5.7)min vs(31.6±4.6)min,P＜0.05],and the shallow sedation compliance rate was higher than that in the propofol group(72.6％vs 44.5％,P＜0.05).The incidence of hypoten-sion,bradycardia,elevated lactate,increased central venous pressure and increased dosage of pressor agent in the remimazolam group were lower than those in the propofol group(19.5％vs 32.1％,P＜0.05;17.2％vs 22.0％,P＜0.05;14.9％vs 22.9％,P＜0.05;4.6％vs 20.2％,P＜0.05;6.9％vs 28.4％,P＜0.05).The mechanical ventilation time and hospitali-zation time in the remimazolam group were shorter than those in the propofol group(5.0 d vs9.0 d,P＜0.05;11.0 d vs 16.0d,P＜0.05).Conclusion Compared with propofol combined with remifentanil,remimazolam combined with remifen-tanil in elderly patients with cardiac insufficiency in Intensive Care Unit can better shorten the onset time,and increase the con-trollability of sedation depth.It has more stable hemodynamics and can shorten the mechanical ventilation time and hospitaliza-tion time.关键词
老年/心功能不全/瑞马唑仑/丙泊酚/镇静镇痛Key words
elderly/cardiac insufficiency/remimazolam/propofol/sedation/analgesia引用本文复制引用
谯明,王俊英,文刚,严婷,刘捷,朱晴,熊双霞,彭雪刚,汪佳莉,岳金芳..瑞马唑仑联合瑞芬太尼用于老年心功能不全患者的镇静镇痛的效果研究[J].老年医学与保健,2025,31(2):438-442,5.基金项目
中国红十字基金会医学赋能公益专项基金"医学赋能与人才培养计划"科研项目(CRCF-YXFN-202201053) （CRCF-YXFN-202201053）
