老年医学与保健2025，Vol.31Issue(2)：519-523,5.
机会性定量CT分析老年人群骨肌健康特征
Analysis of bone and muscle health characteristics of elderly population by means of opportunistic quantitative computed tomo-graphy
摘要
Abstract
Objective To analyze bone and muscle mass of elderly population by means of opportunistic quantitative computed tomography(QCT).Methods 221 elderly volunteers(≥ 60 years old)who underwent low-dose chest CT plain scan physical examination in Tenth Peoples Hospital Affiliated to Tongji University from May 2021 to September 2022 were en-rolled.QCT was used to measure the average volumetric bone mineral density(vBMD)of L1/L2 vertebral bodies,skeletal mus-cle area(SMA),intermuscular adipose tissue(IMAT)area,and skeletal muscle mass index(SMI).Sarcopenia was diagnosed based on SMI,grip strength,and 6-meter gait speed.The differences in muscle parameters and grip strength were compared among the normal bone mass group,osteopenia group and osteoporosis(OP)group,and the correlation between muscle parame-ters and vBMD were analyzed.Results Among 221 volunteers,50 ones were diagnosed with OP and 19 ones with sarcopenia.The detection rate of OP in females was higher than that in males(28.95％vs 15.89％,P=0.020),while there was no statisti-cally significant difference in the detection rate of sarcopenia between different genders(P=0.565).Among elderly males,com-pared with the normal bone mass group,the SMI L2 and SMIparaspinal muscle decreased in the osteopenia group,and SML2 decreased in the OP group(P＜0.05);IMATL2,IMATparaspinal muscle,IMAT/SMIL2,and IMAT/SMAparaspinal muscle increased in the osteopenia group;IMATL2,IMATabdominal wall muscle,IMATparaspinal muscle,IMAT/SMIL2,IMAT/SMAabdominal wall muscle,and IMAT/SMAparaspinal muscle increased in the OP group,while grip strength decreased,with statistically significant differences(P＜0.05).Among elderly women,compared with the normal bone mass group,the OP group showed an increase in IM ATL2,IMATabdominal wall muscle,IMAT/SMIL2 and IMAT/SMAabdominal wall muscle,and a decrease in grip strength,with statistical significance(P＜0.05).Com-pared with the osteopenia group,the IMATabdominal wall muscle and IMAT/SMAabdominal wall muscle in the OP group increased significantly(P＜0.05).There is a weak positive correlation between SMIparaspinal muscle and vBMD,but the correlation disappears after adjus-ting for age factor(male:r=0.067,P=0.538;female:r=0.136,P=0.176).There was a negative correlation(P＜0.05)between IMAT,IMAT/SMA,and vBMD in all groups.After adjusting for age factor,IMATparaspinal muscle remained nega-tively correlated with vBMD(male:r=-0.258,P=0.011;female:r=-0.212,P=0.030).Conclusion Decreased bone mass in the elderly is accompanied by decreased paraspinal muscle mass,increased IMAT and decreased grip strength.Muscle health impairment may promote the occurrence of OP.关键词
老年/定量CT/骨质疏松症/肌少症/体积骨密度Key words
elderly/quantitative computed tomography/osteoporosis/sarcopenia/volumetric bone mineral density引用本文复制引用
汤欢,陈明月,李松,贾睿,张丽丽,汤光宇..机会性定量CT分析老年人群骨肌健康特征[J].老年医学与保健,2025,31(2):519-523,5.基金项目
上海市科委科技创新行动计划(20Y11911800) （20Y11911800）
