人工晶体学报2025，Vol.54Issue(5)：890-897,8.DOI:10.16553/j.cnki.issn1000-985x.2024.0286
缺陷氨氟复合功能化UiO-66的制备及其青蒿琥酯吸附性能的研究
Preparation of Defective Ammonia-Fluorine Composite Functionalized UiO-66 and Its Artesunate Adsorption Properties
摘要
Abstract
Artesunate,a sesquiterpenoid antimalarial drug derived from artemisinin,has attracted attentions of pharmaceutical scientists due to its specific effect on malaria parasites.However,the extraction process of artesunate is complex,requiring a large amount of organic solvents and high energy consumption.The easily modifiable and porous properties of metal-organic framework materials were used to construct a functionalized UiO-66 for the study of artesunate adsorption property.Amino and thiol groups were selected as hydrophilic and hydrophobic groups,and their influences on the adsorption properties for artesunate at different ratios were studied.Considering that the pore size of UiO-66 is smaller than that of artemether,a defect type functionalized zirconium based MOF was constructed by adding an appropriate amount of water molecules to enhance its pore size.The experimental results show that the adsorption capacity of fluorinated aminated UiO-66 is 10 mg/g higher than that of UiO-66 monomer.The defect fluorinated amination UiO-66 has increased adsorption capacity of 33.0 mg/g,demonstrating superior adsorption property.This experiment significantly improved the adsorption capacity and selectivity through the rational design and modification of materials,providing a potential industrial application solution for the purification and production of drugs such as artesunate.关键词
MOF/UiO-66/缺陷氨氟/青蒿琥酯/吸附性能Key words
MOF/UiO-66/defective ammonia-fluorine/artesunate/adsorption property分类
化学化工引用本文复制引用
王子豪,刘嘉钰,董子豪,王宇鑫,许雅旭,朱禹..缺陷氨氟复合功能化UiO-66的制备及其青蒿琥酯吸附性能的研究[J].人工晶体学报,2025,54(5):890-897,8.基金项目
泰州市科技支撑计划(TS202424) （TS202424）
江苏省大学生创新创业训练项目(202412917077Y) （202412917077Y）
