农业生物技术学报2025，Vol.33Issue(6)：1369-1381,13.DOI:10.3969/j.issn.1674-7968.2025.06.017
病毒感染调控宿主MEK/ERK信号通路的研究进展
Research Progress on the Regulation of Host MEK/ERK Signaling Pathway by Viral Infection
摘要
Abstract
The mitogen-activated protein kinase kinase/extracellular regulated protein kinases(MEK/ERK)signaling pathway is a crucial intracellular signal transduction system that plays a pivotal role in regulating fundamental cellular processes including cell proliferation,differentiation,and apoptosis and so on.Recent studies have demonstrated that this signaling pathway also serves important regulatory functions in virus-host interactions.This paper comprehensively reviews the research progress on how viruses modulate biological processes such as apoptosis,autophagy,and the production and secretion of inflammatory factors through the MEK/ERK signaling pathway.Furthermore,it also provides an in-depth analysis of the current research status and potential therapeutic applications of MEK/ERK signaling pathway inhibitors as promising antiviral strategies.This review offers significant theoretical foundations and new research directions for the development of antiviral drugs.关键词
MEK/ERK信号通路/细胞/病毒/凋亡/自噬/炎症因子/抗病毒药物Key words
MEK/ERK signaling pathway/Cell/Virus/Apoptosis/Autophagy/Inflammatory factors/Antiviral drugs分类
农业科技引用本文复制引用
曾建宇,高鹏,周磊,盖新娜,周琼琼,韩军,郭鑫,张永宁,杨汉春..病毒感染调控宿主MEK/ERK信号通路的研究进展[J].农业生物技术学报,2025,33(6):1369-1381,13.基金项目
"十四五"重点研发计划(2021YFD1800100) （2021YFD1800100）
国家现代农业产业技术体系(CARS-35) （CARS-35）
