山东中医杂志2025，Vol.44Issue(5)：532-538,7.DOI:10.16295/j.cnki.0257-358x.2025.05.009
益气泻肺利水法治疗老年心力衰竭合并肺部感染患者临床研究
Clinical Study on Treatment of Elderly Patients with Heart Failure Complicated by Pulmonary Infection Using Method of Benefiting Qi,Purging Lung,and Promoting Diuresis
摘要
Abstract
Objective:To observe the influence of the method of benefiting qi,purging the lung,and promoting diuresis on the cardiopulmonary endurance,ventricular remodeling,and fibrinolytic indexes of elderly patients with heart failure complicated by pulmonary infection.Methods:A total of 102 elderly patients with heart failure complicated by pulmonary infection were selected and divided into the control group and the observation group,each consisting of 51 cases,using the random number table method.During the study process,2 cases dropped out in the control group,leaving a final total of 49 cases.In the observation group,2 cases dropped out and 1 case was excluded due to an aggravated condition,resulting in a final total of 48 cases.The patients in the control group were treated with basic symptomatic treatment of Western medicine,while the patients in the observation group were treated with the method of benefiting qi,purging the lung,and promoting diuresis on this basis.Both groups were treated continuously for 7 days.The traditional Chinese medicine(TCM)syndrome scores,cardiopulmonary endurance indicators(anaerobic threshold oxygen uptake,peak oxygen uptake),six-minute walk test(6MWT)distance,ventricular remodeling indicators(left ventricular ejection fraction,left ventricular mass index,myocardial energy consumption,E peak deceleration time),inflammatory indicators[tumor necrosis factor-α(TNF-α),macrophage inflammatory protein-1 α(MIP-1 α)],myocardial injury indicators[heart-type fatty acid binding protein(H-FABP),plasminogen activator inhibitor-1(PAI-1)],and adverse reactions of the two groups of patients before and after treatment were observed,and the clinical efficacy of the two groups was evaluated.Results:After treatment,the scores of TCM syndrome,left ventricular mass index,myocardial energy consumption,E peak deceleration time,and the levels of MIP-1 α,TNF-α,H-FABP,and PAI-1 in both groups were lower than those before treatment(P＜0.05),and those in the observation group were lower than those in the control group(P＜0.05).The anaerobic threshold oxygen uptake,peak oxygen uptake,6MWT distance,and left ventricular ejection fraction in both groups were higher than those before treatment(P＜0.05),and those in the observation group were higher than those in the control group(P＜0.05).After the treatment,the total effective rate of the observation group was 97.91％,and that of the control group was 81.63％.The comparison of clinical efficacy between the two groups was statistically significant(Z=2.412,P=0.009).Conclusions:The method of benefiting qi,purging the lung,and promoting diuresis has the effects of reducing inflammatory responses,lowering the degree of myocardial cell injury,improving ventricular remodeling and fibrinolytic index levels,and enhancing cardiopulmonary endurance and cardiac function in elderly patients with heart failure complicated by pulmonary infection.关键词
益气泻肺利水法/老年/心力衰竭/肺部感染/炎症/心室重构/纤维蛋白溶解/心肺耐力Key words
the method of benefiting qi,purging the lung,and promoting diuresis/the elderly/heart failure/pulmonary infection/inflammation/ventricular remodeling/fibrinolysis/cardiopulmonary endurance分类
中医学引用本文复制引用
黄晨,朱美玲,王满..益气泻肺利水法治疗老年心力衰竭合并肺部感染患者临床研究[J].山东中医杂志,2025,44(5):532-538,7.基金项目
安徽省重大疑难疾病中西医协同攻关项目(编号:AHWJ2021ab218) （编号:AHWJ2021ab218）
